2. Gene
  3. SMYD3 - SET and MYND domain containing 3 Gene

SMYD3 - SET and MYND domain containing 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含 SET 和 MYND 域 3

种属: Homo sapiens

同用名: KMT3E; ZMYND1; ZNFN3A1; bA74P14.1

基因 ID: 64754 | 基因类型: protein coding

关于 SMYD3

Cytogenetic location: 1q44 Genomic coordinates (GRCh38): 1:245,749,347-246,507,279 (from NCBI)

This gene has 18 transcripts (splice variants), 231 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 1.8), brain (RPKM 1.2) and 25 other tissues.

功能概要

该基因编码一种组蛋白甲基转移酶，该酶通过与特定的 RNA 解旋酶相互作用在 RNA 聚合酶 II 复合物中起作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a Histone Methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

SMYD3 基因产物(19)

mRNA Protein Name
XM_047428021.1 XP_047283977.1 histone-lysine N-methyltransferase SMYD3 isoform X2
NM_001375962.1 NP_001362891.1 histone-lysine N-methyltransferase SMYD3 isoform 3
XM_024449136.2 XP_024304904.1 histone-lysine N-methyltransferase SMYD3 isoform X2
NM_001375966.1 NP_001362895.1 histone-lysine N-methyltransferase SMYD3 isoform 5
XM_011544259.4 XP_011542561.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_024449149.2 XP_024304917.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_011544257.2 XP_011542559.1 histone-lysine N-methyltransferase SMYD3 isoform X4
XM_017002094.3 XP_016857583.1 histone-lysine N-methyltransferase SMYD3 isoform X5
NM_001375965.1 NP_001362894.1 histone-lysine N-methyltransferase SMYD3 isoform 4
XM_047428019.1 XP_047283975.1 histone-lysine N-methyltransferase SMYD3 isoform X1
XM_047428020.1 XP_047283976.1 histone-lysine N-methyltransferase SMYD3 isoform X2
NM_001167740.2 NP_001161212.1 histone-lysine N-methyltransferase SMYD3 isoform 1
NM_022743.3 NP_073580.1 histone-lysine N-methyltransferase SMYD3 isoform 2
XM_024449162.2 XP_024304930.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_047428022.1 XP_047283978.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_024449141.2 XP_024304909.1 histone-lysine N-methyltransferase SMYD3 isoform X5
XM_011544254.3 XP_011542556.1 histone-lysine N-methyltransferase SMYD3 isoform X3
NM_001375963.1 NP_001362892.1 histone-lysine N-methyltransferase SMYD3 isoform 2
XM_011544261.4 XP_011542563.1 histone-lysine N-methyltransferase SMYD3 isoform X5
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone H4 methyltransferase activity IMP
IMP: 通过突变表型推断
25738358 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25738358 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
25738358 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMYD3 蛋白结构

zf-MYND

zf-MYND: MYND finger (2 - 28)

SET

SET: SET domain (79 - 180)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
蛋白主名 其他名称

histone-lysine N-methyltransferase SMYD3

SET and MYND domain-containing protein 3

zinc finger MYND domain-containing protein 1

zinc finger protein, subfamily 3A (MYND domain containing), 1

zinc finger, MYND domain containing 1

重组 SMYD3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76080 SMYD3 Protein, Human (sf9, GST) Q9H7B4-3 (K35-S369) ≥95%
HY-P76081 SMYD3 Protein, Human (HEK293, His-Flag) Q9H7B4-1 (M1-S428) ≥95%
HY-P700258 Histone-lysine N-methyltransferase SMYD3(SMYD3) Protein, Human (His-Myc) Q9H7B4-1 (M1-S428) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-21972 BCI-121 Inhibitor 99.26% 否
HY-19324 EPZ031686 Inhibitor 99.71% 否
HY-104009A GSK2807 Trifluoroacetate Inhibitor 99.36% 否
HY-112080 BAY-6035 Inhibitor 99.82% 否
HY-151379 EM127 Inhibitor 98.37% 否
HY-128352 SMYD3-IN-1 Inhibitor 98.01% 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-152228 SMYD3-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SMYD3 MGD MGI:1916976
Macaca mulatta SMYD3 VGNC VGNC:77713
Rattus norvegicus SMYD3 RGD RGD:1562635
Bos taurus SMYD3 VGNC VGNC:35044
Felis catus SMYD3 VGNC VGNC:107943
Others SMYD3 NCBI
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