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  2. GINS3 - GINS complex subunit 3 Gene

GINS3 - GINS complex subunit 3 Gene

中文名称:轧棉厂复杂亚基 3

种属: Homo sapiens

同用名: PSF3

基因 ID: 64785 | 基因类型: protein coding

关于 GINS3

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,392,471-58,406,147 (from NCBI)

This gene has 10 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in lymph node (RPKM 4.0), testis (RPKM 3.9) and 25 other tissues.

功能概要

该基因编码 GINS 异四聚体复合物的蛋白质亚基,这对于真核生物中 DNA 复制的启动和复制体进展至关重要。已经描述了编码不同同种型的选择性剪接转录物变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GINS3 基因产物(3)

mRNA Protein Name
NM_001126129.2 NP_001119601.1 DNA replication complex GINS protein PSF3 isoform a
NM_001126130.2 NP_001119602.1 DNA replication complex GINS protein PSF3 isoform c
NM_022770.4 NP_073607.2 DNA replication complex GINS protein PSF3 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19805216 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA unwinding involved in DNA replication IDA
IDA: 通过直接分析推断
22474384 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CMG complex IPI
IPI: 通过物理相互作用推断
22474384 GOA
part of GINS complex IPI
IPI: 通过物理相互作用推断
17417653 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22474384 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GINS3 蛋白结构

Sld5

Sld5: GINS complex protein (67 - 173)

  • 0
  • 100
  • 200
  • 216 a.a.
蛋白主名 其他名称

DNA replication complex GINS protein PSF3

GINS complex subunit 3 (Psf3 homolog)

GINS3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GINS3 Q9BRX5 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
26871637
Intra GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Validated Y2H
26871637
Intra GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Y2H Array
26871637
Intra GINS3 Q9BRX5 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra GINS3 Q9BRX5 ICAM5 Homo sapiens Q9UMF0
Validated Y2H
32814053
Intra GINS3 Q9BRX5 ICAM5 Homo sapiens Q9UMF0
Y2H Array
32814053
Intra GINS3 Q9BRX5 ICAM5 Homo sapiens Q9UMF0
Y2H Pooling
32814053
Intra GINS3 Q9BRX5 UQCRB Homo sapiens P14927
Validated Y2H
32814053
Intra GINS3 Q9BRX5 UQCRB Homo sapiens P14927
Y2H Pooling
32814053
Intra GINS3 Q9BRX5 UQCRB Homo sapiens P14927
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus GINS3 VGNC VGNC:62555
Rattus norvegicus GINS3 RGD RGD:1308153
Mus musculus GINS3 MGD MGI:1926083
Bos taurus GINS3 VGNC VGNC:29362
Canis familiaris GINS3 VGNC VGNC:41222
Macaca mulatta GINS3 VGNC VGNC:73014