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  2. DDX31 - DEAD-box helicase 31 Gene

DDX31 - DEAD-box helicase 31 Gene

中文名称:死盒解旋酶 31

种属: Homo sapiens

同用名: PPP1R25

基因 ID: 64794 | 基因类型: protein coding

关于 DDX31

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,592,997-132,669,983 (from NCBI)

This gene has 5 transcripts (splice variants), 186 orthologues and 38 paralogues. Ubiquitous expression in thyroid (RPKM 4.3), ovary (RPKM 2.4) and 25 other tissues.

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程,例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式,该 DEAD 盒蛋白家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码该家族的一个成员。该成员的功能尚未确定。该基因的选择性剪接会产生编码不同异构体的多个转录变体。[RefSeq 提供,2016 年 4 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]

DDX31 基因产物(7)

mRNA Protein Name
NM_001322340.2 NP_001309269.2 probable ATP-dependent RNA helicase DDX31 isoform 3
NM_001322341.2 NP_001309270.1 probable ATP-dependent RNA helicase DDX31 isoform 4
NM_001322342.1 NP_001309271.1 probable ATP-dependent RNA helicase DDX31 isoform 5
NM_001322343.1 NP_001309272.1 probable ATP-dependent RNA helicase DDX31 isoform 6
NM_001322344.2 NP_001309273.2 probable ATP-dependent RNA helicase DDX31 isoform 7
NM_022779.9 NP_073616.7 probable ATP-dependent RNA helicase DDX31 isoform 1
NM_138620.2 NP_619526.2 probable ATP-dependent RNA helicase DDX31 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23019224 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ribosome biogenesis IMP
IMP: 通过突变表型推断
23019224 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
23019224 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DDX31 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (255 - 431)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (553 - 602)

DUF4217

DUF4217: Domain of unknown function (DUF4217) (642 - 681)

  • 0
  • 200
  • 400
  • 600
  • 778 a.a.
蛋白主名 其他名称

probable ATP-dependent RNA helicase DDX31

DEAD (Asp-Glu-Ala-Asp) box polypeptide 31

DDX31 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DDX31 Q9H8H2 SRP14 Homo sapiens P37108
Anti Tag CoIP
33961781
种属内
DDX31 Q9H8H2 SRP14 Homo sapiens P37108
Crosslink
30021884
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Skin Sarcoma

Cutaneous Sarcoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus DDX31 MGD MGI:2682639
Felis catus DDX31 VGNC VGNC:61405
Rattus norvegicus DDX31 RGD RGD:1304895
Bos taurus DDX31 VGNC VGNC:27963
Macaca mulatta DDX31 VGNC VGNC:71631