FBXL17 - F-box and leucine rich repeat protein 17 Gene

中文名称：F-box 和富亮氨酸的重复蛋白 17

种属: Homo sapiens

同用名: Fbl17; Fbx13; FBXO13

基因 ID: 64839 | 基因类型: protein coding

关于 FBXL17

Cytogenetic location: 5q21.3 Genomic coordinates (GRCh38): 5:107,859,035-108,382,098 (from NCBI)

This gene has 4 transcripts (splice variants), 236 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 4.5), brain (RPKM 4.2) and 25 other tissues.

功能概要

F-box 蛋白家族的成员，例如 FBXL17，以大约 40 个氨基酸的 F-box 基序为特征。由 SKP1 (MIM 601434) 、cullin (参见 CUL1；MIM 603134) 和 F-box 蛋白形成的 SCF 复合物充当蛋白质-泛素连接酶。 F-box 蛋白通过 F-box 与 SKP1 相互作用，并且它们通过其他蛋白质相互作用域与泛素化目标相互作用 (Jin 等人，2004 [PubMed 15520277]) 。[OMIM 提供，2008 年 3 月]

Members of the F-box protein family, such as FBXL17, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXL17 基因产物(1)

mRNA	Protein	Name
NM_001163315.3	NP_001156787.2	F-box/LRR-repeat protein 17

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24035498	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	24035498	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	30190310	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	27234298	GOA
involved in protein quality control for misfolded or incompletely synthesized proteins	IDA IDA: 通过直接分析推断	30190310	GOA
involved in protein ubiquitination	IDA IDA: 通过直接分析推断	24035498	GOA
involved in regulation of smoothened signaling pathway	IMP IMP: 通过突变表型推断	27234298	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SCF ubiquitin ligase complex	IDA IDA: 通过直接分析推断	24035498	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	24035498	GOA
located in nucleus	IDA IDA: 通过直接分析推断	24035498	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FBXL17 蛋白结构

F-box-like

0
200
400
600
701 a.a.

蛋白主名

其他名称

F-box/LRR-repeat protein 17

F-box only protein 13

FBXL17 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FBXL17	Q9UF56	SPAST	Homo sapiens	Q9UBP0	Protein Array	35869491
种属内	FBXL17	Q9UF56	KBTBD8	Homo sapiens	Q8NFY9	Anti Tag CoIP	30190310
种属内	FBXL17	Q9UF56	SKP1	Homo sapiens	P63208	Anti Tag CoIP	30190310
种属内	FBXL17	Q9UF56	SKP1	Homo sapiens	P63208	Pull Down	30190310
种属内	FBXL17	Q9UF56	SPAST	Homo sapiens	Q9UBP0-1	Pull Down	35869491
种属内	FBXL17	Q9UF56	SPAST	Homo sapiens	Q9UBP0-1	Anti Tag CoIP	35869491
种属内	FBXL17	Q9UF56	KLHL12	Homo sapiens	Q53G59	Anti Tag CoIP	30190310
种属内	FBXL17	Q9UF56	KLHL12	Homo sapiens	Q53G59	Pull Down	30190310

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder With Cardiac Arrhythmia

Gnb5-Related Intellectual Disability-Cardiac Arrhythmia Syndrome	IDDCA
Intellectual Developmental Disorder, With Cardiac Arrhythmia

Proprotein Convertase 1/3 Deficiency

Obesity Due To Prohormone Convertase I Deficiency	Obesity With Impaired Prohormone Processing
Obesity And Endocrinopathy Due To Impaired Processing Of Prohormones	Pci Deficiency
Proprotein Convertase 1 3 Deficiency	Endocrinopathy Due To Proprotein Convertase 1/3 Deficiency
Proprotein Convertase 1 Deficiency	PC1 DEFICIENCY

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04786	FBXL17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FBXL17	MGD	MGI:1354704
Canis familiaris	FBXL17	VGNC	VGNC:59022
Macaca mulatta	FBXL17	VGNC	VGNC:82142
Felis catus	FBXL17	VGNC	VGNC:102205
Bos taurus	FBXL17	VGNC	VGNC:106738
Rattus norvegicus	FBXL17	RGD	RGD:1309773

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FBXL17 - F-box and leucine rich repeat protein 17 Gene

关于 FBXL17

功能概要

FBXL17 基因产物(1)

FBXL17 蛋白结构

FBXL17 蛋白互作信息

关联疾病

直系同源

热门区域

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FBXL17 - F-box and leucine rich repeat protein 17 Gene

关于 FBXL17

功能概要

FBXL17 基因产物(1)

FBXL17 蛋白结构

FBXL17 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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Z