UPF3A - UPF3A regulator of nonsense mediated mRNA decay Gene

中文名称：UPF3A 调节无义介导的 mRNA 衰变

种属: Homo sapiens

同用名: UPF3; HUPF3A; RENT3A

关于 UPF3A

功能概要

该基因编码的蛋白质是参与 mRNA 核输出和 mRNA 监视的剪接后多蛋白复合物的一部分。编码的蛋白质是酵母 Upf3p 的两个功能同系物之一。 mRNA 监测检测具有截短开放阅读框的输出 mRNA，并启动无义介导的 mRNA 衰变 (NMD) 。当翻译在最后一个外显子-外显子连接处的上游结束时，这会触发 NMD 降解含有过早终止密码子的 mRNA。这种蛋白质与 mRNA 结合并在核输出后保持结合，充当核质穿梭蛋白。它与 Y14 形成一个复合体，该复合体特异性结合外显子-外显子连接上游 20 nt。该基因位于 13 号染色体的长臂上。已发现该基因的几种编码不同亚型的剪接变体。[RefSeq 提供，2017 年 7 月]

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]