2. Gene
  3. Limk1 - LIM domain kinase 1 Gene

Limk1 - LIM domain kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：L IM 结构域激酶 1

种属: Rattus norvegicus

基因 ID: 65172 | 基因类型: protein coding

关于 Limk1

Primary_assembly 12: 22,026,672-22,060,606 forward strand.mRatBN7.2:CM026985.1

This gene has 3 transcripts (splice variants), 262 orthologues, 23 paralogues and is associated with 11 phenotypes. Biased expression in Brain (RPKM 42.9), Adrenal (RPKM 25.5) and 9 other tissues.

功能概要

预计该基因编码的蛋白具有热休克蛋白结合活性和蛋白丝氨酸/苏氨酸激酶活性。预计参与多个过程，包括泛素蛋白转移酶活性的负调控；细胞成分组织的正调控；和蛋白质磷酸化。位于多种细胞成分中，包括高尔基体；轴突生长锥；和细胞质的核周区。与人类 LIMK1（LIM 结构域激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable heat shock protein binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of ubiquitin-protein transferase activity; positive regulation of cellular component organization; and protein phosphorylation. Located in several cellular components, including Golgi apparatus; axonal growth cone; and perinuclear region of cytoplasm. Orthologous to human LIMK1 (LIM domain kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Limk1 基因产物(1)

mRNA Protein Name
NM_031727.2 NP_113915.2 LIM domain kinase 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of modification of postsynaptic actin cytoskeleton IDA
IDA: 通过直接分析推断
25884247 RGD
involved in regulation of modification of postsynaptic actin cytoskeleton IMP
IMP: 通过突变表型推断
25884247 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axonal growth cone IDA
IDA: 通过直接分析推断
15090620 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
25884247 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
25884247 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15090620 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Limk1 蛋白结构

LIM1_LIMK1

LIM1_LIMK1: cd09462 (4 - 76)

LIM2_LIMK1

LIM2_LIMK1: cd09464 (83 - 137)

PDZ

PDZ: pfam00595 (164 - 254)

STKc_LIMK1

STKc_LIMK1: cd14221 (344 - 610)

  • 0
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  • 600
  • 647 a.a.
蛋白主名 其他名称

LIM domain kinase 1

LIM motif-containing protein kinase 1

LIM-domain containing, protein kinase 1

LIMK-1

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136848 SM1-71 Inhibitor 96.09% 否
HY-18305 BMS-5 Inhibitor 99.51% 否
HY-18304 BMS-3 Inhibitor 99.71% 否
HY-122630 TH-257 Inhibitor 98.36% 否
HY-19353 SR7826 Inhibitor 99.30% 否
HY-120025 CRT0105950 Inhibitor 99.91% 否
HY-148061 DB1113 99.28% 否
HY-151539 TH470 Inhibitor 99.57% 否
HY-120097 R-10015 Inhibitor 99.72% 否
HY-14227 LIMK-IN-1 Inhibitor 99.33% 否
HY-128062 LIMK1 inhibitor BMS-4 Inhibitor ≥99.0% 否
HY-N10868 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide Inhibitor / 否
HY-169605 LIMK1 inhibitor 1 Inhibitor / 否
HY-12659B LX7101 monohydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Limk1 NCBI NCBI:3984
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