2. Gene
  3. SLC3A2 - solute carrier family 3 member 2 Gene

SLC3A2 - solute carrier family 3 member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 3 成员 2

种属: Homo sapiens

同用名: 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC

基因 ID: 6520 | 基因类型: protein coding

关于 SLC3A2

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,856,109-62,888,860 (from NCBI)

This gene has 41 transcripts (splice variants), 275 orthologues and 7 paralogues. Ubiquitous expression in kidney (RPKM 68.6), bone marrow (RPKM 41.5) and 25 other tissues.

功能概要

该基因是溶质载体家族的一员，编码细胞表面跨膜蛋白。该蛋白质以异二聚体的重链形式存在，通过二硫键与几种可能的轻链之一共价结合。编码的转运蛋白在调节细胞内钙水平和转运 L 型氨基酸方面发挥作用。编码不同同种型的可变剪接转录物变体已被表征。[RefSeq 提供，2010 年 11 月]

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible LIGHT chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type Amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]

SLC3A2 基因产物(4)

mRNA Protein Name
NM_001012662.3 NP_001012680.1 4F2 cell-surface antigen heavy chain isoform b
NM_001012664.3 NP_001012682.1 4F2 cell-surface antigen heavy chain isoform e
NM_001013251.3 NP_001013269.1 4F2 cell-surface antigen heavy chain isoform f
NM_002394.6 NP_002385.3 4F2 cell-surface antigen heavy chain isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-alanine transmembrane transporter activity IGI
IGI: 通过遗传相互作用推断
10391915 GOA
enables L-leucine transmembrane transporter activity IGI
IGI: 通过遗传相互作用推断
10391915 GOA
enables aromatic amino acid transmembrane transporter activity IGI
IGI: 通过遗传相互作用推断
15589117 GOA
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
21266579 GOA
enables exogenous protein binding IDA
IDA: 通过直接分析推断
30341327 GOA
enables neutral L-amino acid secondary active transmembrane transporter activity IDA
IDA: 通过直接分析推断
33298890 GOA
enables neutral L-amino acid transmembrane transporter activity IGI
IGI: 通过遗传相互作用推断
17197568 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9878049 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
33298890 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-alanine import across plasma membrane IGI
IGI: 通过遗传相互作用推断
10391915 GOA
involved in L-histidine transport IDA
IDA: 通过直接分析推断
9751058 GOA
involved in L-leucine import across plasma membrane IGI
IGI: 通过遗传相互作用推断
10391915 GOA
involved in L-leucine transport IDA
IDA: 通过直接分析推断
9751058 GOA
involved in L-leucine transport IMP
IMP: 通过突变表型推断
30341327 GOA
involved in isoleucine transport IDA
IDA: 通过直接分析推断
11311135 GOA
involved in methionine transport IDA
IDA: 通过直接分析推断
11557028 GOA
involved in phenylalanine transport IDA
IDA: 通过直接分析推断
9751058 GOA
involved in phenylalanine transport IGI
IGI: 通过遗传相互作用推断
15589117 GOA
involved in proline transport IDA
IDA: 通过直接分析推断
10574970 GOA
acts upstream of or within response to exogenous dsRNA IMP
IMP: 通过突变表型推断
21266579 GOA
involved in symbiont entry into host cell IMP
IMP: 通过突变表型推断
30341327 GOA
involved in thyroid hormone transport IDA
IDA: 通过直接分析推断
11564694 GOA
involved in tryptophan transport IDA
IDA: 通过直接分析推断
10574970 GOA
involved in tyrosine transport IDA
IDA: 通过直接分析推断
11557028 GOA
involved in valine transport IDA
IDA: 通过直接分析推断
11557028 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of amino acid transport complex IDA
IDA: 通过直接分析推断
30867591 GOA
located in apical plasma membrane IDA
IDA: 通过直接分析推断
31791063 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
31791063 GOA
located in cell surface IDA
IDA: 通过直接分析推断
25063885 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11311135 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC3A2 蛋白结构

Alpha-amylase

Alpha-amylase: Alpha amylase, catalytic domain (239 - 320)

Alpha-amylase

Alpha-amylase: Alpha amylase, catalytic domain (321 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 630 a.a.
蛋白主名 其他名称

4F2 cell-surface antigen heavy chain

CD98 heavy chain

重组 SLC3A2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75368 CD98 Protein, Human (HEK293, His) P08195-1 (R206-A630) ≥95%

关联疾病

疾病名称 别名
Lysinuric Protein Intolerance

LPI

Dibasic Amino Aciduria Ii

Hyperdibasic Aminoaciduria

Dibasic Aminoaciduria 2

Dibasicamino Aciduria Ii

Congenital Lysinuria

Lpi - Lysinuric Protein Intolerance
Cystinuria

CSNU

Cystinuria Type B

Cystinuria Type A

Cystinuria, Type I, Formerly

Csnu1, Formerly

Cystinuria, Type Ii, Formerly

Cystinuria, Type Iii, Formerly

Csnu3, Formerly

Cystinuria, Type Non-I, Formerly

Cystinuria-Lysinuria

Cystinuria-Lysinuria Syndrome

Csnu1

Csnu3

Cystinuria 1

Cystinuria Type A/B

Cystinuria Type I

Cystinuria Type Ii

Cystinuria Type Iii

Cystinuria Type Non-I

Cystinuria, Type A/B

Cystinuria Type 1

Cystinuria - Lysinuria

Csnu - [Cystinuria]

Cystine Disease
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus
Choriocarcinoma

Chorioepithelioma
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Null-Cell Leukemia

Null Cell Acute Lymphoblastic Leukemia

Null Cell Acute Lymphoblastic Leukaemia

Null-Cell Leukaemia
Colon Carcinoma In Situ

Carcinoma In Situ Of Colon

Stage 0 Colonic Carcinoma

Stage 0 Carcinoma Of Colon

Intraepithelial Neoplasia Of Colon, High Grade

Carcinoma In Situ Of Cecum

Carcinoma In Situ Of Hepatic Flexure

Carcinoma In Situ Of Ileocecal Valve

Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Lung Pleomorphic Carcinoma
Hartnup Disorder

Hartnup Disease

HND

Neutral 1 Amino Acid Transport Defect

Neutral Amino Acid Transport Defect

Deficiency Of Tryptophan Oxygenase

Hartnup'S Disease

Aminoaciduria, Hartnup Type

Disorder Of Neutral Amino Acid Transport
Akinetopsia
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13242 SLC3A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC3A2 RGD RGD:3073
Mus musculus SLC3A2 MGD MGI:96955
Macaca mulatta SLC3A2 VGNC VGNC:77463
Bos taurus SLC3A2 VGNC VGNC:34871
Canis familiaris SLC3A2 VGNC VGNC:46410
Felis catus SLC3A2 VGNC VGNC:65366
Others SLC3A2 NCBI
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