2. Gene
  3. SLC15A2 - solute carrier family 15 member 2 Gene

SLC15A2 - solute carrier family 15 member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 15 成员 2

种属: Homo sapiens

同用名: PEPT2

基因 ID: 6565 | 基因类型: protein coding

关于 SLC15A2

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,894,401-121,944,188 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues and 4 paralogues. Biased expression in prostate (RPKM 19.8), brain (RPKM 10.1) and 13 other tissues.

功能概要

哺乳动物肾脏表达质子偶联肽转运蛋白，负责从管状滤液中吸收小肽以及 β-内酰胺抗生素和其他肽类药物。这种转运蛋白 SLC15A2 与 SLC15A1 (MIM 600544) 属于同一基因家族，SLC15A1 (MIM 600544) 是在小肠中发现的质子偶联肽转运蛋白 (Liu 等人，1995 [PubMed 7756356]) 。[OMIM 提供，2011 年 2 月]

The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small Peptides, as well as Beta-lactam Antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

SLC15A2 基因产物(2)

mRNA Protein Name
NM_001145998.2 NP_001139470.1 solute carrier family 15 member 2 isoform b
NM_021082.4 NP_066568.3 solute carrier family 15 member 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables dipeptide transmembrane transporter activity IDA
IDA: 通过直接分析推断
7756356 GOA
enables peptide:proton symporter activity IDA
IDA: 通过直接分析推断
7756356 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16738539 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antibacterial innate immune response IDA
IDA: 通过直接分析推断
20406817 GOA
involved in dipeptide import across plasma membrane IDA
IDA: 通过直接分析推断
7756356 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in phagocytic vesicle membrane IDA
IDA: 通过直接分析推断
20406817 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC15A2 蛋白结构

PTR2

PTR2: POT family (111 - 491)

  • 0
  • 200
  • 400
  • 600
  • 729 a.a.
蛋白主名 其他名称

solute carrier family 15 member 2

kidney H(+)/peptide cotransporter

SLC15A2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC15A2 Q16348 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra SLC15A2 Q16348 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra SLC15A2 Q16348 KRTAP15-1 Homo sapiens Q3LI76
Validated Y2H
32296183
Intra SLC15A2 Q16348 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra SLC15A2 Q16348 SMARCC1 Homo sapiens Q92922
Validated Y2H
32296183
Intra SLC15A2 Q16348 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra SLC15A2 Q16348 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
32296183
Intra SLC15A2 Q16348 C11orf87 Homo sapiens Q6NUJ2
Validated Y2H
32296183
Intra SLC15A2 Q16348 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra SLC15A2 Q16348 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra SLC15A2 Q16348 TENT5B Homo sapiens Q96A09
Validated Y2H
32296183
Intra SLC15A2 Q16348 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
Intra SLC15A2 Q16348 CHRD Homo sapiens Q9H2X0
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Coproporphyria, Hereditary

Hereditary Coproporphyria

Coproporphyria

Coproporphyrinogen Oxidase Deficiency

HCP

Cpo Deficiency

Cpox Deficiency

Cpx Deficiency

Hereditary Coproporphyria Porphyria

Cpro Deficiency

Coproporphyria Hereditary

Porphyria Hepatica Ii

Porphyria Hepatica Coproporphyria

Porphyria, Hereditary Coproporphyria

Harderoporphyria
Porphyria Cutanea Tarda

Hepatoerythropoietic Porphyria

HEP

Uroporphyrinogen Decarboxylase Deficiency

Pct

Pct, Type Ii

Porphyria, Hepatocutaneous Type

Urod Deficiency

Porphyria, Hepatoerythropoietic

Porphyria Cutanea Tarda, Susceptibility To

Familial Porphyria Cutanea Tarda

Porphyria Cutanea Tarda, Type Ii

Pct, 'Familial' Type

Porphyria, Hepatic

FPCT

Pct Type Ii

Porphyria Cutanea Tarda Type Ii

Porphyria Hepatocutaneous Type

Heterozygous Uroporphyrinogen Decarboxylase Deficiency

Urod - [Uroporphyrinogen Decarboxylase] Deficiency

Pct - [Porphyria Cutanea Tarda]
Variegate Porphyria

Porphyria Variegata

Protoporphyrinogen Oxidase Deficiency

VP

Ppox Deficiency

Porphyria, South African Type

Porphyria Variegata, Susceptibility To

Protocoproporphyria

Porphyria Variegate

Porphyria South African Type

Pv

Porphyria, Variegate

Vp - [Variegate Porphyria]
Porphyria, Acute Intermittent

Acute Intermittent Porphyria

Porphobilinogen Deaminase Deficiency

Pbgd Deficiency

AIP

Porphyria, Swedish Type

Uroporphyrinogen Synthase Deficiency

Ups Deficiency

Porphyria, Acute Intermittent, Nonerythroid Variant

Hydroxymethylbilane Synthase Deficiency

Aip - Acute Intermittent Porphyria

Porphyria Intermittent Acute

Pyrroloporphyria

Hmbs Deficiency

Porphyria Acute Intermittent
Hypotrichosis 4

HYPT4

Marie Unna Hereditary Hypotrichosis 1

Muhh1

Hypotrichosis, Marie Unna Type, 1

Hypotrichosis Marie Unna 1

Marie Unna Hereditary Hypotrichosis Type 1

Hypotrichosis, Hereditary, Marie Unna Type, 1

Hypotrichosis, Type 4
Acute Porphyria

Porphyrias, Hepatic

Hepatic Porphyria

Porphyria Hepatic

Acute Intermittent Porphyria
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13013 SLC15A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SLC15A2 VGNC VGNC:65201
Rattus norvegicus SLC15A2 RGD RGD:61972
Macaca mulatta SLC15A2 VGNC VGNC:77394
Canis familiaris SLC15A2 VGNC VGNC:46233
Mus musculus SLC15A2 MGD MGI:1890457
Others SLC15A2 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z