2. Gene
  3. SLC22A1 - solute carrier family 22 member 1 Gene

SLC22A1 - solute carrier family 22 member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 22 成员 1

种属: Homo sapiens

同用名: OCT1; HOCT1; oct1_cds

基因 ID: 6580 | 基因类型: protein coding

关于 SLC22A1

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,121,815-160,158,718 (from NCBI)

This gene has 7 transcripts (splice variants), 495 orthologues and 22 paralogues. Restricted expression toward liver (RPKM 121.5).

功能概要

肝脏、肾脏、肠道和其他器官中的多特异性有机阳离子转运蛋白对于消除许多内源性小有机阳离子以及多种药物和环境毒素至关重要。该基因是位于 6 号染色体簇中的三个相似阳离子转运蛋白基因之一。编码的蛋白质包含十二个假定的跨膜结构域，是一种血浆整合膜蛋白。已发现该基因编码两种不同亚型的两种转录变体，但只有较长的变体编码功能性转运蛋白。[RefSeq 提供，2008 年 7 月]

Polyspecific organic cation transporters in the liver, kidney, intestine, and Other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]

SLC22A1 基因产物(2)

mRNA Protein Name
NM_003057.3 NP_003048.1 solute carrier family 22 member 1 isoform a
NM_153187.2 NP_694857.1 solute carrier family 22 member 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylcholine transmembrane transporter activity IDA
IDA: 通过直接分析推断
15817714 GOA
enables monoamine transmembrane transporter activity IDA
IDA: 通过直接分析推断
9260930 GOA
enables neurotransmitter transmembrane transporter activity IDA
IDA: 通过直接分析推断
12439218 GOA
enables organic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
11907186 GOA
enables organic cation transmembrane transporter activity EXP
EXP: 通过实验结果推断
19141712 GOA
enables organic cation transmembrane transporter activity IDA
IDA: 通过直接分析推断
9260930 GOA
enables prostaglandin transmembrane transporter activity IDA
IDA: 通过直接分析推断
11907186 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11543633 GOA
enables putrescine transmembrane transporter activity IDA
IDA: 通过直接分析推断
21128598 GOA
enables pyrimidine nucleoside transmembrane transporter activity IMP
IMP: 通过突变表型推断
20477935 GOA
enables quaternary ammonium group transmembrane transporter activity IDA
IDA: 通过直接分析推断
23567998 GOA
enables toxin transmembrane transporter activity IDA
IDA: 通过直接分析推断
22806583 GOA
enables toxin transmembrane transporter activity IMP
IMP: 通过突变表型推断
20477935 GOA
enables xenobiotic transmembrane transporter activity IDA
IDA: 通过直接分析推断
9260930 GOA
enables xenobiotic transmembrane transporter activity IMP
IMP: 通过突变表型推断
20477935 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetylcholine transport IDA
IDA: 通过直接分析推断
15817714 GOA
involved in cellular detoxification IDA
IDA: 通过直接分析推断
22806583 GOA
involved in cellular detoxification IMP
IMP: 通过突变表型推断
20477935 GOA
involved in dopamine transport IDA
IDA: 通过直接分析推断
35469921 GOA
involved in dopamine uptake IDA
IDA: 通过直接分析推断
24688079 GOA
involved in epinephrine transport IDA
IDA: 通过直接分析推断
35469921 GOA
involved in monoamine transport IDA
IDA: 通过直接分析推断
35469921 GOA
involved in neurotransmitter transport IDA
IDA: 通过直接分析推断
24688079 GOA
involved in norepinephrine transport IDA
IDA: 通过直接分析推断
24688079 GOA
involved in organic cation transport IDA
IDA: 通过直接分析推断
22806583 GOA
involved in prostaglandin transport IDA
IDA: 通过直接分析推断
11907186 GOA
involved in putrescine transport IDA
IDA: 通过直接分析推断
21128598 GOA
involved in quaternary ammonium group transport IDA
IDA: 通过直接分析推断
23567998 GOA
involved in serotonin transport IDA
IDA: 通过直接分析推断
12439218 GOA
involved in serotonin uptake IDA
IDA: 通过直接分析推断
24688079 GOA
involved in thiamine transmembrane transport IDA
IDA: 通过直接分析推断
24961373 GOA
involved in thiamine transport IDA
IDA: 通过直接分析推断
24961373 GOA
involved in xenobiotic transport IDA
IDA: 通过直接分析推断
9260930 GOA
involved in xenobiotic transport IMP
IMP: 通过突变表型推断
20477935 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15817714 GOA
located in basal plasma membrane IDA
IDA: 通过直接分析推断
35307651 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
12719534 GOA
located in lateral plasma membrane IDA
IDA: 通过直接分析推断
16263091 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC22A1 蛋白结构

Sugar_tr

Sugar_tr: Sugar (and other) transporter (144 - 523)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 554 a.a.
蛋白主名 其他名称

solute carrier family 22 member 1

organic cation transporter 1

SLC22A1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC22A1 O15245 CERS2 Homo sapiens Q96G23
Pull Down
11543633
种属内
SLC22A1 O15245 CERS2 Homo sapiens Q96G23
Y2H
21988832
种属内
SLC22A1 O15245 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

SLC22A1 抗体

目录号 产品名 应用 反应物种
HY-P82681 SLC22A1 Antibody (YA2426) WB, FC Human

关联疾病

疾病名称 别名
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
Chromosome 17q23.1-Q23.2 Deletion Syndrome

17q23.1q23.2 Microdeletion Syndrome

17q23.1-Q23.2 Microdeletion Syndrome

Del(17)(Q23.1q23.2)

Monosomy 17q23.1q23.2

Monosomy 17q23.1-Q23.2
Diabetes Mellitus

Diabetes
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13061 SLC22A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SLC22A1 VGNC VGNC:77417
Rattus norvegicus SLC22A1 RGD RGD:3224
Mus musculus SLC22A1 MGD MGI:108111
Bos taurus SLC22A1 VGNC VGNC:34719
Canis familiaris SLC22A1 VGNC VGNC:46270
Felis catus SLC22A1 VGNC VGNC:97629
Others SLC22A1 NCBI
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