2. Gene
  3. SLC22A1 - solute carrier family 22 member 1 Gene

SLC22A1 - solute carrier family 22 member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 22 成员 1

种属: Homo sapiens

同用名: OCT1; HOCT1; oct1_cds

基因 ID: 6580 | 基因类型: protein coding

关于 SLC22A1

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,121,815-160,158,718 (from NCBI)

This gene has 7 transcripts (splice variants), 495 orthologues and 22 paralogues. Restricted expression toward liver (RPKM 121.5).

功能概要

肝脏、肾脏、肠道和其他器官中的多特异性有机阳离子转运蛋白对于消除许多内源性小有机阳离子以及多种药物和环境毒素至关重要。该基因是位于 6 号染色体簇中的三个相似阳离子转运蛋白基因之一。编码的蛋白质包含十二个假定的跨膜结构域，是一种血浆整合膜蛋白。已发现该基因编码两种不同亚型的两种转录变体，但只有较长的变体编码功能性转运蛋白。[RefSeq 提供，2008 年 7 月]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]

SLC22A1 基因产物(2)

mRNA Protein Name
NM_003057.3 NP_003048.1 solute carrier family 22 member 1 isoform a
NM_153187.2 NP_694857.1 solute carrier family 22 member 1 isoform b

SLC22A1 蛋白结构

Sugar_tr

Sugar_tr: Sugar (and other) transporter (144 - 523)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 554 a.a.
蛋白主名 其他名称

solute carrier family 22 member 1

organic cation transporter 1

关联疾病

疾病名称 别名
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
Chromosome 17q23.1-Q23.2 Deletion Syndrome

17q23.1q23.2 Microdeletion Syndrome

17q23.1-Q23.2 Microdeletion Syndrome

Del(17)(Q23.1q23.2)

Monosomy 17q23.1q23.2

Monosomy 17q23.1-Q23.2
Diabetes Mellitus

Diabetes
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13061 SLC22A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SLC22A1 VGNC VGNC:77417
Rattus norvegicus SLC22A1 RGD RGD:3224
Mus musculus SLC22A1 MGD MGI:108111
Bos taurus SLC22A1 VGNC VGNC:34719
Canis familiaris SLC22A1 VGNC VGNC:46270
Felis catus SLC22A1 VGNC VGNC:97629
Others SLC22A1 NCBI
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