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  2. LPAR3 - lysophosphatidic acid receptor 3 Gene

LPAR3 - lysophosphatidic acid receptor 3 Gene

中文名称:溶血磷脂酸受体 3

种属: Rattus norvegicus

同用名: Edg7

基因 ID: 66025 | 基因类型: protein coding

关于 LPAR3

Primary_assembly 2: 235,149,065-235,193,357 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 196 orthologues and 18 paralogues. Biased expression in Kidney (RPKM 59.9), Lung (RPKM 38.6) and 7 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白 α 亚基结合活性和磷脂结合活性。参与磷脂酶 C 激活 G 蛋白偶联信号通路中钙离子转运的正向调节和细胞溶质钙离子浓度的正向调节。预测位于轴突。预计在细胞质和质膜中有活性。与人类 LPAR3(溶血磷脂酸受体 3)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in positive regulation of calcium ion transport and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Predicted to be located in axon. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

LPAR3 基因产物(1)

mRNA Protein Name
NM_023969.2 NP_076459.2 lysophosphatidic acid receptor 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G-protein alpha-subunit binding IMP
IMP: 通过突变表型推断
16504475 RGD
enables phospholipid binding IMP
IMP: 通过突变表型推断
16504475 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
16504475 RGD
involved in positive regulation of calcium ion transport IMP
IMP: 通过突变表型推断
11340076 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LPAR3 蛋白结构

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (30 - 303)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (31 - 57)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (64 - 89)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (101 - 131)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (144 - 162)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (182 - 211)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (231 - 261)

7tmA_LPAR3_Edg7

7tmA_LPAR3_Edg7: cd15343 (271 - 296)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
蛋白主名 其他名称

lysophosphatidic acid receptor 3

LPA receptor 3

LPA-3

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7

lysophosphatidic acid receptor Edg-7

putative G protein-coupled receptor snGPCR32

snGPCR32

直系同源

种属 基因名 来源 基因 ID
Homo sapiens LPAR3 NCBI NCBI:23566