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  3. Tnik - TRAF2 and NCK interacting kinase Gene

Tnik - TRAF2 and NCK interacting kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：TRAF2 和 NCK 相互作用激酶

种属: Mus musculus

同用名: 1500031A17Rik; 4831440I19Rik; C530008O15Rik; C630040K21Rik

基因 ID: 665113 | 基因类型: protein coding

关于 Tnik

Chromosome 3: 28,317,363-28,730,007 forward strand.GRCm39:CM000996.3

This gene has 18 transcripts (splice variants), 268 orthologues, 35 paralogues and is associated with 20 phenotypes. Broad expression in frontal lobe adult (RPKM 7.4), cortex adult (RPKM 5.7) and 18 other tissues.

功能概要

预测该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。参与调节神经递质受体定位到突触后特化膜。在谷氨酸能突触中活跃。该基因的人类直系同源物与常染色体隐性非综合征性智力障碍有关。与人类 TNIK（TRAF2 和 NCK 相互作用激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable protein serine/threonine kinase activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Apr 2022]

Tnik 基因产物(4)

mRNA Protein Name
NM_026910.1 NP_081186.1 traf2 and NCK-interacting protein kinase isoform 1
NM_001163009.1 NP_001156481.1 traf2 and NCK-interacting protein kinase isoform 4
NM_001163008.1 NP_001156480.1 traf2 and NCK-interacting protein kinase isoform 3
NM_001163007.1 NP_001156479.1 traf2 and NCK-interacting protein kinase isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20159449 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
23035106 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: 通过突变表型推断
23035106 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
23035106 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
23035106 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tnik 蛋白结构

STKc_TNIK

STKc_TNIK: cd06637 (17 - 312)

CNH

CNH: smart00036 (1041 - 1339)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1360 a.a.
蛋白主名 其他名称

traf2 and NCK-interacting protein kinase

相关产品

Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100830 NCB-0846 Inhibitor 99.61% 否
HY-111754 DMX-5804 Inhibitor 99.83% 否
HY-10371 Pim1/AKK1-IN-1 Inhibitor 98.20% 否
HY-124745 KY-05009 99.24% 否
HY-145293 TNIK-IN-3 Inhibitor 99.88% 否
HY-160623 INS018 055 Inhibitor 99.38% 否
HY-124762 TNIK-IN-1 98.86% 否
HY-156816 ON 108600 Inhibitor 99.73% 否
HY-143437 TNIK-IN-5 Inhibitor 99.75% 否
HY-N3127 Orobol Inhibitor 99.28% 否
HY-156817 TNIK-IN-6 96.92% 否
HY-156818 TNIK-IN-7 99.90% 否
HY-156502 TINK-IN-1 Inhibitor 98.02% 否
HY-162314 TNIK-IN-8 Inhibitor / 否
HY-RS14832 Tnik Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-143436 TNIK-IN-4 Inhibitor / 否
HY-145292 TNIK-IN-2 99.68% 否
HY-156523 TNIK&MAP4K4-IN-1 / 否
HY-163478 TNIK-IN-9 Inhibitor / 否
HY-RS14831 TNIK Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14833 Tnik Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tnik NCBI NCBI:23043
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