BPI - bactericidal permeability increasing protein Gene

中文名称：杀菌通透性增加蛋白

种属: Homo sapiens

同用名: rBPI; BPIFD1

基因 ID: 671 | 基因类型: protein coding

关于 BPI

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,304,156-38,337,505 (from NCBI)

This gene has 6 transcripts (splice variants), 123 orthologues and 12 paralogues. Restricted expression toward bone marrow (RPKM 549.1).

功能概要

该基因编码脂多糖结合蛋白。它与人中性粒细胞颗粒有关，对革兰氏阴性菌具有抗菌活性。[RefSeq 提供，2014 年 11 月]

This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]

BPI 基因产物(1)

mRNA	Protein	Name
NM_001725.3	NP_001716.3	bactericidal permeability-increasing protein precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables lipopolysaccharide binding	IDA IDA: 通过直接分析推断	8409400	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antibacterial humoral response	IDA IDA: 通过直接分析推断	1937776	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	1937776	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: 通过直接分析推断	1937776	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: 通过直接分析推断	1937776	GOA
involved in negative regulation of interleukin-6 production	IDA IDA: 通过直接分析推断	8409400	GOA
involved in negative regulation of interleukin-8 production	IDA IDA: 通过直接分析推断	8409400	GOA
involved in negative regulation of macrophage activation	IDA IDA: 通过直接分析推断	8409400	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: 通过直接分析推断	8409400	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	1937776	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BPI 蛋白结构

LBP_BPI_CETP

LBP_BPI_CETP_C

0
100
200
300
400
487 a.a.

蛋白主名

其他名称

bactericidal permeability-increasing protein

BPI fold containing family D, member 1

重组 BPI 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7644	BPI Protein, Human (HEK293, His)	AAH40955.1 (V32-K487)	≥95%

关联疾病

疾病名称

别名

Meningococcemia

Reactive Arthritis

Postdysenteric Arthropathy	Reiter Disease
Pira	Reiter Syndrome
Reiters Syndrome	Arthritis, Reactive
Fiessinger Leroy Reiter Syndrome	Post-Bacterial Arthropathy
Reiter'S Disease	Post-Infectious Arthritis
Post-Infectious Reactive Arthropathy	Reiter'S Syndrome
Arthritis Urethritica	Fiessinger-Leroy Disease
Polyarthritis Enterica	Venereal Arthritis
Arthritis Reactive	Post-Dysenteric Arthropathy
Arthritis, Venereal

Vasculitis

Angiitis	Autoimmune Vasculitis
Systemic Vasculitis	Vasculitis, Autoimmune

Bronchiectasis

Polynesian Bronchiectasis	Kartagener Syndrome
Bronchiectasis Nos

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Dacryocystitis

Nasolacrimal Sac Infection

Acute Inflammation Of Lacrimal Passage

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Toxic Shock Syndrome

Septic Shock	Toxic Shock
Tss	Shock, Septic
Staphylococcal Toxic Shock Syndrome	Tss - [Toxic Shock Syndrome]

Alpha-1-Antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency	Alpha-1 Antitrypsin Deficiency
Aat Deficiency	Aatd
A1ATD	Emphysema Due To Aat Deficiency
A1at Deficiency	Emphysema-Cirrhosis, Due To Aat Deficiency
Hemorrhagic Diathesis Due To Antithrombin Pittsburgh	Alpha-1 Antiprotease Deficiency
Alpha 1 Antitrypsin Deficiency	Aat
Alpha-1 Protease Inhibitor Deficiency	Alpha-1 Related Emphysema
Genetic Emphysema	Hereditary Pulmonary Emphysema
Inherited Emphysema	Alpha-1-Proteinase Inhibitor Deficiency
Alpha1-Antitrypsin Deficiency	Alpha-1-Antitrypsin Deficiency, Autosomal Recessive
Emphysema, Hereditary Pulmonary	Aatd - [Alpha-1-Antitrypsin] Deficiency

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Bacteremia 2

Bacteremia	Bacteremia, Susceptibility To, 2
BACTS2	Bacteremia, Susceptibility To
Bacteremia, Susceptibility To, Type 2

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-15164A	Icotinib	Inhibitor	99.99%	是
HY-15164	Icotinib Hydrochloride	Inhibitor	99.81%	是

目录号	产品名	作用方式	纯度	Phase
HY-114356	BPI-9016M	Inhibitor	97.12%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-109189	Rezivertinib	Inhibitor	99.43%	否
HY-141703A	DC-BPi-11 hydrochloride	Inhibitor	≥97.0%	否
HY-150211	DC-BPi-03	Inhibitor	99.77%	否
HY-141703	DC-BPi-11	Inhibitor	/	否
HY-15164AS	Icotinib-d4		/	否
HY-RS01580	BPI Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-164464	BPI-15086	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	BPI	RGD	RGD:1303179
Mus musculus	BPI	MGD	MGI:3045315
Canis familiaris	BPI	VGNC	VGNC:49649
Felis catus	BPI	VGNC	VGNC:60152
Bos taurus	BPI	VGNC	VGNC:97246
Macaca mulatta	BPI	VGNC	VGNC:70277
Others	BPI	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BPI - bactericidal permeability increasing protein Gene

关于 BPI

功能概要

BPI 基因产物(1)

BPI 蛋白结构

重组 BPI 蛋白

关联疾病

直系同源

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BPI - bactericidal permeability increasing protein Gene

关于 BPI

功能概要

BPI 基因产物(1)

BPI 蛋白结构

重组 BPI 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z