SRM - spermidine synthase Gene

中文名称：亚精胺合酶

种属: Homo sapiens

同用名: PAPT; SPS1; SPDSY; SRML1

基因 ID: 6723 | 基因类型: protein coding

关于 SRM

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,054,589-11,060,018 (from NCBI)

This gene has 6 transcripts (splice variants), 219 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 19.8), lymph node (RPKM 14.2) and 25 other tissues.

功能概要

多胺腐胺、精胺和亚精胺是细胞生长和分化的普遍存在的聚阳离子介质。亚精胺合酶是多胺生物合成途径中的四种酶之一，负责亚精胺生物合成的最后一步。该酶使用脱羧 S-腺苷甲硫氨酸作为辅因子催化腐胺转化为亚精胺。[RefSeq 提供，2008 年 7 月]

The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four Enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This Enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]

SRM 基因产物(1)

mRNA	Protein	Name
NM_003132.3	NP_003123.2	spermidine synthase

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	17585781	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21044950	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	17585781	GOA
enables spermidine synthase activity	IDA IDA: 通过直接分析推断	17585781	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in spermidine biosynthetic process	IDA IDA: 通过直接分析推断	17585781	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRM 蛋白结构

Spermine_synth

0
100
200
302 a.a.

蛋白主名

其他名称

spermidine synthase

putrescine aminopropyltransferase

SRM 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SRM	P19623	SRM	Homo sapiens	P19623	X-Ray Diffraction	17585781
种属内	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Prey Pooling	32296183
种属内	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Array	32296183
种属内	SRM	P19623	TERF1	Homo sapiens	P54274	Pull Down	21044950
种属内	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Array	29892012
种属内	SRM	P19623	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	31515488
种属内	SRM	P19623	TERF1	Homo sapiens	P54274	BiFC	21044950
种属内	SRM	P19623	SRM	Homo sapiens	P19623	Y2H Array	31515488
种属内	SRM	P19623	SRM	Homo sapiens	P19623	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Chagas Disease

American Trypanosomiasis	Chagas' Disease
Chagas' Disease With Digestive System Involvement	Chagas' Disease With Nervous System Involvement
Chagas' Disease With Other Organ Involvement	Infection Due To Trypanosoma Cruzi
South American Trypanosomiasis	Chronic Chagas Disease With Digestive System Involvement

Leishmaniasis

Post-Kala-Azar Dermal Leishmaniasis	Post Kala-Azar Dermal Leishmaniasis
Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis	Cutaneous Leishmaniasis
Kala-Azar	Visceral Leishmaniasis
Leishmaniasis, Cutaneous	Leishmaniasis, Visceral
Leishmania	Leishmania Infection
Leishmaniosis

Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome	Mental Retardation, X-Linked, Snyder-Robinson Type
Spermine Synthase Deficiency	Srs
Snyder-Robinson Mental Retardation Syndrome	X-Linked Intellectual Disability Snyder-Robinson Type
Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type	Snyder-Robinson X-Linked Mental Retardation Syndrome

Secondary Progressive Multiple Sclerosis

Secondary-Progressive Ms	Spms
Multiple Sclerosis, Chronic Progressive	Chronic Progressive Multiple Sclerosis
Multiple Sclerosis, Secondary Progressive

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-120111	MW-150	Inhibitor	99.89%	否
HY-131028	Janelia Fluor® 646 TFA		≥95.0%	否
HY-131029	Janelia Fluor® 646, Maleimide		≥95.0%	否
HY-P3146S	FTISADTSK-13C6,15N2 TFA		99.02%	否
HY-P3146A	FTISADTSK acetate		99.66%	否
HY-131026	Janelia Fluor® 635, SE		99.30%	否
HY-120796	MW108 hydrochloride	Inhibitor	/	否
HY-P3146	FTISADTSK		/	否
HY-RS13769	SRM Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS13770	SRMS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-152901	Chol-N3		/	否
HY-120111A	MW-150 hydrochloride	Inhibitor	/	否
HY-120111B	MW-150 dihydrochloride dihydrate	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SRM	VGNC	VGNC:35282
Rattus norvegicus	SRM	RGD	RGD:620796
Mus musculus	SRM	MGD	MGI:102690
Canis familiaris	SRM	VGNC	VGNC:46805
Felis catus	SRM	VGNC	VGNC:82543
Others	SRM	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SRM - spermidine synthase Gene

关于 SRM

功能概要

SRM 基因产物(1)

SRM 蛋白结构

SRM 蛋白互作信息

关联疾病

直系同源

热门区域

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SRM - spermidine synthase Gene

关于 SRM

功能概要

SRM 基因产物(1)

SRM 蛋白结构

SRM 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z