SSB - small RNA binding exonuclease protection factor La Gene

中文名称：小 RNA 结合核酸外切酶保护因子 La

种属: Homo sapiens

同用名: La; LARP3; La/SSB

基因 ID: 6741 | 基因类型: protein coding

关于 SSB

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:169,798,871-169,812,064 (from NCBI)

This gene has 12 transcripts (splice variants), 219 orthologues and 6 paralogues. Ubiquitous expression in fat (RPKM 51.7), thyroid (RPKM 36.0) and 25 other tissues.

功能概要

该基因编码的蛋白质参与 RNA 代谢的多个方面，包括结合和保护新生 RNA 聚合酶 III 转录本的 poly (U) 末端免受外切核酸酶消化，处理前 tRNA 前体的 5' 和 3' 末端，充当 RNA 伴侣，以及与丙型肝炎病毒相关的结合病毒 RNA。在干燥综合征和系统性红斑狼疮患者的血清中发现了与这种蛋白质反应的自身抗体。替代启动子的使用导致编码相同蛋白质的两种不同的转录物变体。[RefSeq 提供，2014 年 6 月]

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

SSB 基因产物(2)

mRNA	Protein	Name
NM_001294145.2	NP_001281074.1	lupus La protein
NM_003142.5	NP_003133.1	lupus La protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IMP IMP: 通过突变表型推断	3192525	GOA
enables poly(U) RNA binding	IMP IMP: 通过突变表型推断	12842046	GOA
enables poly(U) RNA binding	IPI IPI: 通过物理相互作用推断	12842046	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23552417	GOA
enables sequence-specific mRNA binding	IMP IMP: 通过突变表型推断	9154801	GOA
enables tRNA binding	IMP IMP: 通过突变表型推断	10983981	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in IRES-dependent viral translational initiation	IDA IDA: 通过直接分析推断	12384597	GOA
involved in nuclear histone mRNA catabolic process	IMP IMP: 通过突变表型推断	9154801	GOA
involved in protein localization to cytoplasmic stress granule	IDA IDA: 通过直接分析推断	24965446	GOA
involved in tRNA 3'-end processing	IGI IGI: 通过遗传相互作用推断	10983981	GOA
involved in tRNA 5'-leader removal	IGI IGI: 通过遗传相互作用推断	10983981	GOA
involved in tRNA export from nucleus	IMP IMP: 通过突变表型推断	17308035	GOA
involved in tRNA processing	IMP IMP: 通过突变表型推断	17308035	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17308035	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17308035	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SSB 蛋白结构

RRM_1

RRM_3

0
100
200
300
408 a.a.

蛋白主名

其他名称

lupus La protein

La ribonucleoprotein domain family, member 3

重组 SSB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73629	SSB Protein, Human (sf9, His)	P05455 (M1-Q408)	≥95%
HY-P73630	SSB Protein, Human (His)	P05455 (M1-Q408)	≥95%
HY-P73630A	SSB Protein, Human	P05455 (M1-Q408)	≥95%

关联疾病

疾病名称

别名

Sjogren Syndrome

Sicca Syndrome	Sjogren'S Syndrome
Sjögren Syndrome	Sjogren-Gougerot Syndrome
Keratoconjunctivitis Sicca	Sjögren'S Syndrome
Xerodermosteosis	Dacryosialoadenopathia Atrophicans
Gougerot-Houwer-Sjogren Syndrome	Gougerot-Sjogren Syndrome
Keratoconjunctivitis Sicca-Xerostomia	Secreto-Inhibitor-Xerodermostenosis
Primary Sjogren Syndrome	Primary Sjogren-Gougerot Syndrome
Sjogrens Syndrome Primary	Sjogrens Syndrome
Dry Eye Syndromes

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Heart Block, Congenital

Congenital Heart Block	Heart Block Congenital
Congenital Atrioventricular Block

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Xerophthalmia

Conjunctival Xerosis

Second-Degree Atrioventricular Block

Second-Degree Heart Block	Second Degree Atrioventricular Block
Second Degree Atrioventricular Heart Block	Second Degree Heart Block
Incomplete Atrioventricular Block, Second Degree Nos	Second-Degree Block, Type 1 And 2
Atrioventricular Block, Type 1 And 2	Second Degree Incomplete Atrioventricular Block
Av - [Atrioventricular] Block 2nd

Autoimmune Disease Of Exocrine System

Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Parotid Disease

Parotid Diseases

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Diffuse Infiltrative Lymphocytosis Syndrome

Mononeuritis Multiplex

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Mononeuritis Of Upper Limb And Mononeuritis Multiplex

Keratoconjunctivitis Sicca

Kcs	Dry Eye Syndromes
Keratitis Sicca	Xerophthalmia

Dry Eye Syndrome

Dry Eye Syndromes	Dry Eye Disease
Tear Film Insufficiency	Xerophthalmia

Third-Degree Atrioventricular Block

Third Degree Atrioventricular Block	Complete Atrioventricular Block
Complete Av Block	Third-Degree Block
Complete Atrioventricular Heart Block	Complete Heart Block
Third Degree Atrioventricular Heart Block	Third Degree Heart Block
Complete Heart Block Nos	Chb - [Complete Heart Block]
Idioventricular Rhythm	Av - [Atrioventricular] Block, Complete

Endocardial Fibroelastosis

Endomyocardial Fibroelastosis	Elastomyofibrosis
EFE	Efe - [Endocardial Fibroelastosis]
Primary Endocardial Fibroelastosis	Fibroelastosis Cordis
Fetal Endocarditis	Fibroelastosis
Congenital Endocardial Fibroelastosis	Congenital Valvular Endocarditis

Chromosomal Deletion Syndrome

Dacryoadenitis

Dacryocystitis

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia	Lip Disease
Lip Diseases	LIP
Disease Of Lips

Systemic Scleroderma

Scleroderma	Progressive Systemic Sclerosis
Systemic Sclerosis	Scleroderma, Systemic
Scleroderma Syndrome	Dermatosclerosis
Familial Progressive Scleroderma	Progressive Scleroderma
Scleroderma Disease	Scleroderma, Localized
Diffuse Scleroderma	Scleroderma, Familial Progressive

Atrioventricular Block

Av Block

Drug-Induced Lupus Erythematosus

Dile	Dil
Drug-Induced Systemic Lupus Erythematosus

Munchausen By Proxy

Munchausen Syndrome By Proxy	Munchausen By Proxy Syndrome
Münchausen Syndrome By Proxy

Sialadenitis

Sialoadenitis	Adenitis, Salivary Gland
Salivary Gland Inflammation	Salivary Gland Adenitis
Sialitis	Inflammation Of Salivary Gland
Inflammation Of Salivary Duct Or Gland	Salivary Glandular Adenitis
Sialoangiitis	Sialoangitis
Sialodochitis

Mononeuropathy

Mononeuropathies

Parotitis

Mikulicz Disease

Igg4-Related Dacryoadenitis And Sialadenitis	Mikulicz'S Disease
Chronic Dacryoadenitis And Sialadenitis	Mikulicz Syndrome
Mikulicz' Disease

Chronic Interstitial Cystitis

Salivary Gland Disease

Salivary Gland Disorders	Salivary Gland Diseases
Non-Neoplastic Salivary Gland Disease	Non-Neoplastic Salivary Gland Disorder
Disorder Of Salivary Gland	Lesion Of Salivary Gland Nos

Aphthous Stomatitis

Oral Ulcer	Canker Sore
Aphtha	Aphthous Ulceration
Oral Aphthae	Oral Aphthous Ulcer
Canker Sores	Stomatitis, Aphthous
Minor Oral Aphthous Ulceration

Chromosomal Disease

Chromosomal Disorders

Congenital Chromosomal Disease

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-10617A	Rucaparib	Inhibitor	99.97%	是
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	是
HY-102003	Rucaparib monocamsylate	Inhibitor	99.82%	是
HY-102003A	Rucaparib camsylate	Inhibitor	/	否

目录号	产品名	作用方式	纯度	Phase
HY-145804	AZD-9574	Inhibitor	99.11%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-137457	Venadaparib	Inhibitor	98.11%	否
HY-RS13804	SSB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W159870	N-Nitrosodibenzylamine	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SSB	VGNC	VGNC:58552
Bos taurus	SSB	VGNC	VGNC:58554
Rattus norvegicus	SSB	RGD	RGD:620804
Felis catus	SSB	VGNC	VGNC:65699
Mus musculus	SSB	MGD	MGI:98423
Others	SSB	NCBI