2. Gene
  3. STC1 - stanniocalcin 1 Gene

STC1 - stanniocalcin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：斯钙素 1

种属: Homo sapiens

同用名: STC

基因 ID: 6781 | 基因类型: protein coding

关于 STC1

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:23,841,929-23,854,806 (from NCBI)

This gene has 2 transcripts (splice variants), 277 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 33.6), thyroid (RPKM 19.7) and 14 other tissues.

功能概要

该基因编码一种分泌型同型二聚体糖蛋白，该糖蛋白在多种组织中表达，并可能具有自分泌或旁分泌功能。该基因包含一个富含 CAG 三核苷酸重复序列的 5' UTR。编码的蛋白质包含 11 个保守的半胱氨酸残基，并且仅在其丝氨酸残基上被蛋白激酶 C 磷酸化。该蛋白质可能在肾脏和肠道钙和磷酸盐转运、细胞代谢或细胞钙/磷酸盐稳态的调节中发挥作用。人斯钙素 1 在小鼠中的过度表达会导致高血清磷酸盐水平、侏儒症和代谢率增加。该基因在肝细胞癌、卵巢癌和乳腺癌中的表达发生了改变。[RefSeq 提供，2008 年 7 月]

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

STC1 基因产物(1)

mRNA Protein Name
NM_003155.3 NP_003146.1 stanniocalcin-1 precursor

STC1 蛋白结构

Stanniocalcin

Stanniocalcin: Stanniocalcin family (1 - 208)

  • 0
  • 100
  • 200
  • 247 a.a.
蛋白主名 其他名称

stanniocalcin-1

重组 STC1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71338 STC1/Stanniocalcin-1 Protein, Human (HEK293, His) P52823 (T18-A247) ≥95%

关联疾病

疾病名称 别名
Fibrosarcoma

Neoplasms, Fibrous Tissue

Fibrocytic Tumor

Fibrosarcoma Of Soft Tissue

Fibrous Tissue Neoplasm
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16228 Stc1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13903 STC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris STC1 VGNC VGNC:46895
Bos taurus STC1 VGNC VGNC:35377
Felis catus STC1 VGNC VGNC:65767
Rattus norvegicus STC1 RGD RGD:621776
Macaca mulatta STC1 VGNC VGNC:84120
Mus musculus STC1 MGD MGI:109131
Others STC1 NCBI
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