STC1 - stanniocalcin 1 Gene

中文名称：斯钙素 1

种属: Homo sapiens

同用名: STC

基因 ID: 6781 | 基因类型: protein coding

关于 STC1

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:23,841,929-23,854,806 (from NCBI)

This gene has 2 transcripts (splice variants), 277 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 33.6), thyroid (RPKM 19.7) and 14 other tissues.

功能概要

该基因编码一种分泌型同型二聚体糖蛋白，该糖蛋白在多种组织中表达，并可能具有自分泌或旁分泌功能。该基因包含一个富含 CAG 三核苷酸重复序列的 5' UTR。编码的蛋白质包含 11 个保守的半胱氨酸残基，并且仅在其丝氨酸残基上被蛋白激酶 C 磷酸化。该蛋白质可能在肾脏和肠道钙和磷酸盐转运、细胞代谢或细胞钙/磷酸盐稳态的调节中发挥作用。人斯钙素 1 在小鼠中的过度表达会导致高血清磷酸盐水平、侏儒症和代谢率增加。该基因在肝细胞癌、卵巢癌和乳腺癌中的表达发生了改变。[RefSeq 提供，2008 年 7 月]

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

STC1 基因产物(1)

mRNA	Protein	Name
NM_003155.3	NP_003146.1	stanniocalcin-1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	26195635	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in bone development	IDA IDA: 通过直接分析推断	16377640	GOA
involved in chondrocyte proliferation	IDA IDA: 通过直接分析推断	16377640	GOA
involved in endothelial cell morphogenesis	IDA IDA: 通过直接分析推断	14500721	GOA
involved in growth plate cartilage axis specification	IDA IDA: 通过直接分析推断	16377640	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: 通过直接分析推断	8700837	GOA
involved in negative regulation of calcium ion transport	IDA IDA: 通过直接分析推断	8700837	GOA
acts upstream of positive effect negative regulation of cell migration	IDA IDA: 通过直接分析推断	17032941	GOA
involved in negative regulation of endothelial cell migration	IDA IDA: 通过直接分析推断	14500721	GOA
involved in negative regulation of renal phosphate excretion	IDA IDA: 通过直接分析推断	8700837	GOA
involved in positive regulation of calcium ion import	IDA IDA: 通过直接分析推断	17032941	GOA
involved in regulation of cardiac muscle cell contraction	IDA IDA: 通过直接分析推断	12663264	GOA
involved in regulation of monoatomic anion transport	IDA IDA: 通过直接分析推断	16377640	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	12663264	GOA
located in nucleus	IDA IDA: 通过直接分析推断	12663264	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STC1 蛋白结构

Stanniocalcin

0
100
200
247 a.a.

蛋白主名

其他名称

stanniocalcin-1

STC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	STC1	P52823	STC1	Homo sapiens	P52823	Comig Non-Denat Gel	26195635
种属内	STC1	P52823	PAPPA	Homo sapiens	Q13219	SPR	26195635
种属内	STC1	P52823	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	STC1	P52823	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	STC1	P52823	STC1	Homo sapiens	P52823	GMS	26195635
种属内	STC1	P52823	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 STC1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71338	STC1/Stanniocalcin-1 Protein, Human (HEK293, His)	P52823-1 (T18-A247)	≥95%

STC1 抗体

目录号	产品名	应用	反应物种
HY-P82945	Stanniocalcin 1 Antibody (YA2690)	WB, IP	Human

关联疾病

疾病名称

别名

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16228	Stc1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS13903	STC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	STC1	VGNC	VGNC:46895
Bos taurus	STC1	VGNC	VGNC:35377
Felis catus	STC1	VGNC	VGNC:65767
Rattus norvegicus	STC1	RGD	RGD:621776
Macaca mulatta	STC1	VGNC	VGNC:84120
Mus musculus	STC1	MGD	MGI:109131
Others	STC1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STC1 - stanniocalcin 1 Gene

关于 STC1

功能概要

STC1 基因产物(1)

STC1 蛋白结构

STC1 蛋白互作信息

重组 STC1 蛋白

STC1 抗体

关联疾病

直系同源

热门区域

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STC1 - stanniocalcin 1 Gene

关于 STC1

功能概要

STC1 基因产物(1)

STC1 蛋白结构

STC1 蛋白互作信息

重组 STC1 蛋白

STC1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z