STYX - serine/threonine/tyrosine interacting protein Gene

中文名称：丝氨酸/苏氨酸/酪氨酸相互作用蛋白

种属: Homo sapiens

基因 ID: 6815 | 基因类型: protein coding

关于 STYX

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:52,730,166-52,774,989 (from NCBI)

This gene has 3 transcripts (splice variants), 221 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种假磷酸酶，能够结合潜在的底物，但缺乏活性催化环。编码的蛋白质可能参与精子发生。已经为这些基因发现了编码相同蛋白质的两种转录物变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]

STYX 基因产物(2)

mRNA	Protein	Name
NM_001130701.2	NP_001124173.1	serine/threonine/tyrosine-interacting protein
NM_145251.4	NP_660294.1	serine/threonine/tyrosine-interacting protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables F-box domain binding	IMP IMP: 通过突变表型推断	28007894	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23847209	GOA
enables pseudophosphatase activity	IMP IMP: 通过突变表型推断	28007894	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process	IMP IMP: 通过突变表型推断	28007894	GOA
involved in negative regulation of protein binding	IDA IDA: 通过直接分析推断	28007894	GOA
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	23847209	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	23847209	GOA
located in nucleus	IDA IDA: 通过直接分析推断	23847209	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STYX 蛋白结构

DSPc

0
100
200
223 a.a.

蛋白主名

其他名称

serine/threonine/tyrosine-interacting protein

inactive tyrosine-protein phosphatase STYX

STYX 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	STYX	Q8WUJ0	FBXW7	Homo sapiens	Q969H0	Anti Bait CoIP	28007894
Intra	STYX	Q8WUJ0	FBXW7	Homo sapiens	Q969H0	Peptide Array	28007894
Intra	STYX	Q8WUJ0	FBXW7	Homo sapiens	Q969H0	Anti Tag CoIP	28007894
Intra	STYX	Q8WUJ0	FBXW7	Homo sapiens	Q969H0	Anti Tag CoIP	27880917
Intra	STYX	Q8WUJ0	FBXW7	Homo sapiens	Q969H0	Pull Down	28007894
Intra	STYX	Q8WUJ0	FBXW7	Homo sapiens	Q969H0-1	Anti Tag CoIP	28007894
Intra	STYX	Q8WUJ0	FBXW7	Homo sapiens	Q969H0-1	BiFC	28007894
Intra	STYX	Q8WUJ0	FBXW7	Homo sapiens	Q969H0-1	Pull Down	28007894
Intra	STYX	Q8WUJ0	FBXW7	Homo sapiens	Q969H0-1	Confocal	28007894

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

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STYX - serine/threonine/tyrosine interacting protein Gene

关于 STYX

功能概要

STYX 基因产物(2)

STYX 蛋白结构

STYX 蛋白互作信息

关联疾病

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STYX - serine/threonine/tyrosine interacting protein Gene

关于 STYX

功能概要

STYX 基因产物(2)

STYX 蛋白结构

STYX 蛋白互作信息

关联疾病

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热门区域

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