VAMP7 - vesicle associated membrane protein 7 Gene

中文名称：囊泡相关膜蛋白 7

种属: Homo sapiens

同用名: SYBL1; TIVAMP; VAMP-7; TI-VAMP

基因 ID: 6845 | 基因类型: protein coding

关于 VAMP7

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,881,345-155,943,769 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues, 10 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 18.0), kidney (RPKM 17.3) and 25 other tissues.

功能概要

该基因编码的跨膜蛋白是可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体 (SNARE) 家族的成员。编码的蛋白质定位于晚期内体和溶酶体，并参与运输囊泡与其靶膜的融合。交替剪接导致多个转录变体。[RefSeq 提供，2010 年 6 月]

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

VAMP7 基因产物(3)

mRNA	Protein	Name
NM_001145149.3	NP_001138621.1	vesicle-associated membrane protein 7 isoform 2
NM_001185183.2	NP_001172112.1	vesicle-associated membrane protein 7 isoform 3
NM_005638.6	NP_005629.1	vesicle-associated membrane protein 7 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16354670	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
NOT involved in autophagosome maturation	IMP IMP: 通过突变表型推断	23217709	GOA
involved in endosome to lysosome transport	IDA IDA: 通过直接分析推断	10888671	GOA
involved in eosinophil degranulation	IMP IMP: 通过突变表型推断	16677249	GOA
involved in natural killer cell degranulation	IMP IMP: 通过突变表型推断	18042464	GOA
involved in neutrophil degranulation	IMP IMP: 通过突变表型推断	16677249	GOA
involved in positive regulation of histamine secretion by mast cell	IMP IMP: 通过突变表型推断	18253931	GOA
involved in vesicle fusion	IDA IDA: 通过直接分析推断	10888671	GOA
involved in vesicle-mediated transport	IDA IDA: 通过直接分析推断	10888671	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of SNARE complex	IDA IDA: 通过直接分析推断	18253931	GOA
located in azurophil granule membrane	IDA IDA: 通过直接分析推断	16677249	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18253931	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	22589474	GOA
located in membrane	IDA IDA: 通过直接分析推断	16677249	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	18253931	GOA
located in platelet alpha granule	IDA IDA: 通过直接分析推断	22589474	GOA
located in pseudopodium	IDA IDA: 通过直接分析推断	22589474	GOA
located in secretory granule	IDA IDA: 通过直接分析推断	18042464	GOA
located in secretory granule membrane	IDA IDA: 通过直接分析推断	16677249	GOA
located in trans-Golgi network	IDA IDA: 通过直接分析推断	19745841	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VAMP7 蛋白结构

Longin

Synaptobrevin

0
100
200
220 a.a.

蛋白主名

其他名称

vesicle-associated membrane protein 7

synaptobrevin-like 1

VAMP7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	VAMP7	P51809	SNAP47	Homo sapiens	Q5SQN1	Anti Tag CoIP	26359495
Intra	VAMP7	P51809	SNAP47	Homo sapiens	Q5SQN1	Pull Down	26359495
Cross	VAMP7	P51809	ap3a_sars2	SARS-CoV-2	P0DTC3	Anti Tag CoIP	34706264
Cross	VAMP7	P51809	ap3a_sars2	SARS-CoV-2	P0DTC3	Confocal	34706264
Intra	VAMP7	P51809	AGFG1	Homo sapiens	P52594	Y2H	18775314
Intra	VAMP7	P51809	AGFG1	Homo sapiens	P52594	ITC	18775314

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Tetanus

Lockjaw	Clostridial Tetanus
Infection Due To Clostridium Tetani	Lock-Jaw

46,Xy Partial Gonadal Dysgenesis

46,Xy Pgd

46,Xy Partial Testicular Dysgenesis

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Deafness, Y-Linked 2

DFNY2

Y-Linked Deafness 2

Mesenteric Lymphadenitis

Mesenteric Adenitis

Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndrome

Cednik Syndrome	CEDNIK
Cerebral Dysgenesis, Neuropathy, Ichthyosis And Keratoderma Syndrome	Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma Syndro
Cerebral Dysgenesis-Neuropathy-Ichthyosis-Palmoplantar Keratoderma Syndrome	Cerebral Dysgenesis-Neuropathy-Ichthyosis-Keratoderma Syndrome
Cerebral Dysgenesis, Neuropathy, Ichthyosis, And Palmoplantar Keratoderma	Neurocutaneous Syndromes

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15598	VAMP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	VAMP7	VGNC	VGNC:48226
Felis catus	VAMP7	VGNC	VGNC:66913
Bos taurus	VAMP7	VGNC	VGNC:107020
Macaca mulatta	VAMP7	VGNC	VGNC:78558
Rattus norvegicus	VAMP7	RGD	RGD:621558
Mus musculus	VAMP7	MGD	MGI:1096399

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

VAMP7 - vesicle associated membrane protein 7 Gene

关于 VAMP7

功能概要

VAMP7 基因产物(3)

VAMP7 蛋白结构

VAMP7 蛋白互作信息

关联疾病

直系同源

热门区域

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VAMP7 - vesicle associated membrane protein 7 Gene

关于 VAMP7

功能概要

VAMP7 基因产物(3)

VAMP7 蛋白结构

VAMP7 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z