TBCA - tubulin folding cofactor A Gene

中文名称：微管蛋白折叠辅助因子 A

种属: Homo sapiens

关于 TBCA

功能概要

该基因的产物是四种蛋白质 (辅助因子 A、D、E 和 C) 之一，参与从折叠中间体到正确折叠的 β-微管蛋白的通路。辅因子 A 和 D 被认为在捕获和稳定 β-微管蛋白中间体中发挥作用，这在准天然证实中发挥了作用。辅因子 E 与辅因子 D/β-微管蛋白复合物结合；然后与辅因子 C 的相互作用会导致释放处于天然状态的 β-微管蛋白多肽。该基因编码伴侣蛋白辅因子 A。已发现该基因编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2014 年 7 月]

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]