2. Gene
  3. TCEA1 - transcription elongation factor A1 Gene

TCEA1 - transcription elongation factor A1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转录延伸因子 A1

种属: Homo sapiens

同用名: SII; TCEA; TF2S; GTF2S; TFIIS

基因 ID: 6917 | 基因类型: protein coding

关于 TCEA1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:53,966,556-54,022,448 (from NCBI)

This gene has 14 transcripts (splice variants), 216 orthologues, 3 paralogues and is associated with 55 phenotypes. Ubiquitous expression in thyroid (RPKM 66.3), lymph node (RPKM 39.6) and 25 other tissues.

功能概要

预测启用 DNA 结合活性；翻译延伸因子活性；和锌离子结合活性。预测参与 RNA 聚合酶 II 对转录的正调控。预测作用于红细胞分化的上游或内部以及转录的正调节，DNA 模板。位于核仁和核质中。转录因子 TFIID 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]

TCEA1 基因产物(2)

mRNA Protein Name
NM_006756.4 NP_006747.1 transcription elongation factor A protein 1 isoform 1
NM_201437.3 NP_958845.1 transcription elongation factor A protein 1 isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20178742 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of transcription factor TFIID complex IDA
IDA: 通过直接分析推断
27193682 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TCEA1 蛋白结构

Med26

Med26: TFIIS helical bundle-like domain (26 - 78)

TFIIS_M

TFIIS_M: Transcription factor S-II (TFIIS), central domain (136 - 250)

TFIIS_C

TFIIS_C: Transcription factor S-II (TFIIS) (261 - 299)

  • 0
  • 100
  • 200
  • 301 a.a.
蛋白主名 其他名称

transcription elongation factor A protein 1

epididymis secretory sperm binding protein

TCEA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TCEA1 P23193 PAF1 Homo sapiens Q8N7H5
Anti Bait CoIP
20178742
Intra TCEA1 P23193 PAF1 Homo sapiens Q8N7H5
Pull Down
20178742
Intra TCEA1 P23193 POLR2A Homo sapiens P24928
Pull Down
20178742
Intra TCEA1 P23193 POLR2A Homo sapiens P24928
Anti Bait CoIP
20178742
Intra TCEA1 P23193 POLR2A Homo sapiens P24928
Pull Down
20562857
Intra TCEA1 P23193 GPKOW Homo sapiens Q92917
Y2H Prey Pooling
32296183
Intra TCEA1 P23193 GPKOW Homo sapiens Q92917
Validated Y2H
32296183
Intra TCEA1 P23193 GPKOW Homo sapiens Q92917
Y2H Array
32296183
Intra TCEA1 P23193 LEO1 Homo sapiens Q8WVC0
Pull Down
20178742
Intra TCEA1 P23193 LEO1 Homo sapiens Q8WVC0
Anti Bait CoIP
20178742
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Uv-Sensitive Syndrome

Uvss

Uv Sensitive Syndrome

Ultraviolet Sensitive Syndrome
De Sanctis-Cacchione Syndrome

Xerodermic Idiocy

Xeroderma Pigmentosum With Neurologic Manifestation

DSC

Xerodermic Idiocy Of De Sanctis And Cacchione
Cockayne Syndrome B

Cockayne Syndrome Type 2

Cockayne Syndrome, Type B

Cockayne Syndrome Type Ii

CSB

Cockayne Syndrome 2

Cockayne Syndrome Type B

Ckn2

Cockayne Syndrome, Type Ii
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14292 TCEA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TCEA1 VGNC VGNC:78279
Mus musculus TCEA1 MGD MGI:1196624
Bos taurus TCEA1 VGNC VGNC:35679
Rattus norvegicus TCEA1 RGD RGD:1309880
Felis catus TCEA1 VGNC VGNC:81681
Canis familiaris TCEA1 VGNC VGNC:47182
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