2. Gene
  3. TCF21 - transcription factor 21 Gene

TCF21 - transcription factor 21 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转录因子 21

种属: Homo sapiens

同用名: POD1; bHLHa23

基因 ID: 6943 | 基因类型: protein coding

关于 TCF21

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:133,889,113-133,895,537 (from NCBI)

This gene has 2 transcripts (splice variants), 218 orthologues and 13 paralogues. Broad expression in placenta (RPKM 32.6), spleen (RPKM 25.0) and 15 other tissues.

功能概要

TCF21 编码基本螺旋-环-螺旋家族的转录因子。 TCF21 产物是中胚层特异性的，在胚胎心外膜、肺、肠、性腺的间充质衍生组织以及肾脏的间充质和肾小球上皮细胞中表达。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

TCF21 基因产物(2)

mRNA Protein Name
NM_003206.4 NP_003197.2 transcription factor 21
NM_198392.3 NP_938206.1 transcription factor 21
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12493738 GOA
enables bHLH transcription factor binding IPI
IPI: 通过物理相互作用推断
12493738 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12493738 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12493738 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TCF21 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (80 - 132)

  • 0
  • 100
  • 179 a.a.
蛋白主名 其他名称

transcription factor 21

capsulin

TCF21 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TCF21 O43680 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
种属内
TCF21 O43680 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
种属内
TCF21 O43680 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
种属内
TCF21 O43680 MYOD1 Homo sapiens P15172
Validated Y2H
32296183
种属内
TCF21 O43680 MYOD1 Homo sapiens P15172
Y2H Array
32296183
种属内
TCF21 O43680 MYOD1 Homo sapiens P15172
Y2H Prey Pooling
32296183
种属内
TCF21 O43680 APP Homo sapiens P05067
Y2H Pooling
32814053
种属内
TCF21 O43680 APP Homo sapiens P05067
Validated Y2H
32814053
种属内
TCF21 O43680 APP Homo sapiens P05067
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

TCF21 抗体

目录号 产品名 应用 反应物种
HY-P82356 Transcription Factor 21 Antibody (YA2101) WB, IP, FC Human

关联疾病

疾病名称 别名
Paralytic Ileus

Adynamic Ileus

Paralytic Ileus Of Bowel

Ileus Nos

Paralysis Of Bowel

Paralysis Of Intestine

Adynamic Intestinal Obstruction

Paralytic Intestinal Ileus
Pain Agnosia

Analgesia
Subacute Lymphocytic Thyroiditis
Pericoronitis

Operculitis
Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia
Peroneal Nerve Paralysis

Peroneal Nerve Palsy
Mediastinitis
Femoral Cancer

Femoral Neoplasms

Cancer Of The Femur

Femoral Neoplasm

Neoplasm Of Femur
Median Arcuate Ligament Syndrome

Celiac Artery Compression Syndrome

Dunbar Syndrome

Mals

Harjola-Marable Syndrome

Marable'S Syndrome

Celiac Axis Syndrome
Spondylolisthesis

Slipped Vertebrae

Acquired Spondylolisthesis
Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome
Aspiration Pneumonia

Pneumonia, Aspiration

Pneumonia Aspiration

Aspiration Pneumonitis
Supine Hypotensive Syndrome

Maternal Hypotension Syndrome

Antepartum Maternal Hypotension Syndrome

Postpartum Maternal Hypotension Syndrome

Maternal Hypotension Syndrome, Antepartum Condition Or Complication

Maternal Hypotension Syndrome, Postpartum Condition Or Complication

Maternal Hypotension Syndrome, Unspecified Trimester
Inguinal Hernia

Hernia Inguinal

Hernia, Inguinal

Inguinal Hernias

Bubonocele

Indirect Inguinal Hernia

Direct Inguinal Hernia

Oblique Inguinal Hernia

Scrotal Hernia

Ih - [Inguinal Hernia]
Specific Developmental Disorder
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14303 TCF21 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TCF21 MGD MGI:1202715
Canis familiaris TCF21 VGNC VGNC:47193
Macaca mulatta TCF21 VGNC VGNC:78286
Felis catus TCF21 VGNC VGNC:66024
Bos taurus TCF21 VGNC VGNC:35690
Rattus norvegicus TCF21 RGD RGD:620523
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