MLX - MAX dimerization protein MLX Gene

中文名称：MAX 二聚化蛋白 MLX

种属: Homo sapiens

同用名: TF4; MAD7; MXD7; TCFL4; bHLHd13

基因 ID: 6945 | 基因类型: protein coding

关于 MLX

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,567,100-42,573,203 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in duodenum (RPKM 29.5), small intestine (RPKM 29.2) and 25 other tissues.

功能概要

该基因的产物属于碱性螺旋-环-螺旋亮氨酸拉链 (bHLH-Zip) 转录因子家族。这些因子与 Mad 蛋白形成异二聚体，并在增殖、决定和分化中发挥作用。该基因产物可能通过与转录抑制子 Mad 家族的一个子集 (即 Mad1 和 Mad4) 的有限关联来使 Mad 家族功能多样化。已经为该基因鉴定了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

MLX 基因产物(3)

mRNA	Protein	Name
NM_170607.3	NP_733752.1	max-like protein X isoform gamma
NM_198204.2	NP_937847.1	max-like protein X isoform beta
NM_198205.2	NP_937848.1	max-like protein X isoform alpha

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	11230181	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	EXP EXP: 通过实验结果推断	14742444	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	10918583	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	10918583	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	10918583	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	11230181	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	11230181	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	11230181	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11230181	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	10918583	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11073985	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10918583	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10918583	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MLX 蛋白结构

HLH

0
100
200
298 a.a.

蛋白主名

其他名称

max-like protein X

BigMax protein

MLX 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MLX	Q9UH92	ZBTB32	Homo sapiens	A0A0C4DGF1	Y2H Array	25416956
种属内	MLX	Q9UH92	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
种属内	MLX	Q9UH92	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
种属内	MLX	Q9UH92	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
种属内	MLX	Q9UH92	GABARAPL2	Homo sapiens	P60520	Y2H Pooling	16189514
种属内	MLX	Q9UH92	GABARAPL2	Homo sapiens	P60520	Validated Y2H	25416956
种属内	MLX	Q9UH92	GABARAPL2	Homo sapiens	P60520	Y2H Array	25416956
种属间	MLX	Q9UH92	HBZ	Human T-lymphotropic virus	Q2Q067	MAPPIT	22458338
种属间	MLX	Q9UH92	HBZ	Human T-lymphotropic virus	Q2Q067	Y2H Pooling	22458338

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ovarian Dysgenesis 3

ODG3	Dysgenesis, Ovarian, Type 3

Takayasu Arteritis

Aortic Arch Syndrome	Pulseless Disease
Takayasu'S Arteritis	Idiopathic Aortitis
Young Female Arteritis	Aortic Arch Arteritis
Aortic Arches Defect	Aortic Arch Defects
Takayasu Disease	Aortic Arch Syndromes
Takayasu'S Disease	Ta
Obliterative Aortitis	Aortic Arch Giant-Cell Arteritis
Subclavian-Carotid Obstruction Syndrome	Idiopathic Medial Aortopathy And Arteriopathy
Takayasu Syndrome	Obliterative Brachiocephalic Arteritis Syndrome
Raeder-Harbitz Syndrome	Chronic Subclavian-Carotid Obstruction Syndrome
Giant-Cell Aortitis	Takayasu Aortitis
Nonspecific Aortoarteritis	Sclerosing Aortitis And Arteritis
Martorell 2 Syndrome	Young Female Aortic Arch Arteritis Syndrome

Dental Fluorosis

Mottled Teeth	Intrinsic Enamel Discolouration Of Fluorosis
Mottling Of Enamel	Fluorosis, Dental
Dental Fluorosis, Acquired

Benign Essential Hypertension

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome

Mrxs13	Lindsay-Burn Syndrome
Ppm-X	Ppm-X Syndrome
Mental Retardation With Psychosis, Pyramidal Signs, And Macroorchidism	Mental Retardation, X-Linked, Syndromic 13
X-Linked Mental Retardation 79	X-Linked Mental Retardation With Spasticity
Intellectual Deficit, X-Linked - Psychosis - Macroorchidism	Intellectual Disability Psychosis Macroorchidism
Intellectual Disability With Psychosis, Pyramidal Signs, And Macroorchidism	Intellectual Disability, X-Linked, Syndromic 13
Ppmx	X-Linked Mental Retardation, Syndromic 13

Olfactory Groove Meningioma

Meningioma Of The Olfactory Groove

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08503	MLX Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MLX	VGNC	VGNC:31508
Mus musculus	MLX	MGD	MGI:108398
Rattus norvegicus	MLX	RGD	RGD:1308590
Canis familiaris	MLX	VGNC	VGNC:43267
Felis catus	MLX	VGNC	VGNC:63528
Macaca mulatta	MLX	VGNC	VGNC:74726

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