TEF - TEF transcription factor, PAR bZIP family member Gene

中文名称：TEF 转录因子，PAR bZIP 家族成员

种属: Homo sapiens

关于 TEF

功能概要

该基因编码碱性区/亮氨酸拉链 (bZIP) 转录因子的 PAR (富含脯氨酸和酸性氨基酸) 亚家族的成员。它在成年动物的广泛细胞和组织中表达，然而，在胚胎发育过程中，TEF 表达似乎仅限于发育中的垂体前叶，与促甲状腺激素 β (TSHB) 的出现一致。事实上，TEF 可以结合并反式激活 TSHB 启动子。它与转录因子 PAR-bZIP 亚家族的其他成员 (包括白蛋白 D 盒结合蛋白 (DBP) 、人肝白血病因子 (HLF) 和鸡卵黄蛋白原基因结合蛋白 (VBP) ) 显示出同源性 (在功能域中) ) ; VBP 被认为是 TEF 的鸡同系物。该亚家族的不同成员可以很容易地形成异二聚体，并共享 DNA 结合和转录调控特性。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 1 月]

This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult Animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with Other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]