2. Gene
  3. TGFB1I1 - transforming growth factor beta 1 induced transcript 1 Gene

TGFB1I1 - transforming growth factor beta 1 induced transcript 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：转化生长因子 beta 1 诱导转录物 1

种属: Homo sapiens

同用名: HIC5; ARA55; HIC-5; TSC-5

基因 ID: 7041 | 基因类型: protein coding

关于 TGFB1I1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,472,152-31,477,960 (from NCBI)

This gene has 17 transcripts (splice variants), 187 orthologues and 2 paralogues. Broad expression in endometrium (RPKM 51.3), prostate (RPKM 29.5) and 20 other tissues.

功能概要

该基因编码雄激素受体的共激活因子，这是一种由雄激素激活的转录因子，在男性性别分化中起着关键作用。编码的蛋白质被认为可以调节雄激素受体的活性，并可能在前列腺癌的治疗中发挥作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 9 月]

This gene encodes a coactivator of the Androgen Receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate Androgen Receptor activity and may have a role to play in the treatment of prostate Cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

TGFB1I1 基因产物(3)

mRNA Protein Name
NM_001042454.3 NP_001035919.1 transforming growth factor beta-1-induced transcript 1 protein isoform 1
NM_001164719.1 NP_001158191.1 transforming growth factor beta-1-induced transcript 1 protein isoform 2
NM_015927.5 NP_057011.2 transforming growth factor beta-1-induced transcript 1 protein isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables I-SMAD binding IPI
IPI: 通过物理相互作用推断
18762808 GOA
enables Roundabout binding IPI
IPI: 通过物理相互作用推断
19855388 GOA
enables nuclear androgen receptor binding IPI
IPI: 通过物理相互作用推断
10075738 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9756887 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
10075738 GOA
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
16624805 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10075738 GOA
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
18762808 GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
18762808 GOA
involved in positive regulation of ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
18762808 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TGFB1I1 蛋白结构

Paxillin

Paxillin: Paxillin family (41 - 107)

LIM

LIM: LIM domain (228 - 283)

LIM

LIM: LIM domain (287 - 342)

LIM

LIM: LIM domain (346 - 400)

LIM

LIM: LIM domain (405 - 460)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
蛋白主名 其他名称

transforming growth factor beta-1-induced transcript 1 protein

androgen receptor coactivator 55 kDa protein

TGFB1I1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
TGFB1I1 O43294 YPMT1.25Ac Yersinia pestis O68743
Y2H Array
21911467
种属内
TGFB1I1 O43294 TRAF4 Homo sapiens Q9BUZ4
Anti Bait CoIP
16330715
种属内
TGFB1I1 O43294 TRAF4 Homo sapiens Q9BUZ4
Pull Down
16330715
种属内
TGFB1I1 O43294 TRAF4 Homo sapiens Q9BUZ4
Confocal
16330715
种属内
TGFB1I1 O43294 TRAF4 Homo sapiens Q9BUZ4
Y2H
16330715
种属内
TGFB1I1 O43294 PTK2 Homo sapiens Q05397
Y2H
21900206
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14438 TGFB1I1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TGFB1I1 VGNC VGNC:47308
Macaca mulatta TGFB1I1 VGNC VGNC:78333
Rattus norvegicus TGFB1I1 RGD RGD:620173
Felis catus TGFB1I1 VGNC VGNC:66132
Bos taurus TGFB1I1 VGNC VGNC:35801
Mus musculus TGFB1I1 MGD MGI:102784
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