2. Gene
  3. TLN1 - talin 1 Gene

TLN1 - talin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：塔林 1

种属: Homo sapiens

同用名: TLN; ILWEQ; talin-1

基因 ID: 7094 | 基因类型: protein coding

关于 TLN1

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,696,948-35,732,195 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 74.7), spleen (RPKM 60.6) and 25 other tissues.

功能概要

该基因编码一种细胞骨架蛋白，该蛋白集中在细胞-基质和细胞-细胞接触区域。编码的蛋白质在肌动蛋白丝的组装以及各种细胞类型 (包括成纤维细胞和破骨细胞) 的扩散和迁移中起着重要作用。它与细胞表面膜中的整联蛋白共同分布，以协助贴壁细胞与细胞外基质的附着以及淋巴细胞与其他细胞的附着。该蛋白质的 N 端包含用于定位到细胞-细胞外基质连接处的元件。 C 末端包含蛋白质的结合位点，例如 β-1-整合素、肌动蛋白和纽蛋白。[RefSeq 提供，2009 年 2 月]

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to Other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

TLN1 基因产物(1)

mRNA Protein Name
NM_006289.4 NP_006280.3 talin-1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables LIM domain binding IPI
IPI: 通过物理相互作用推断
10320340 GOA
enables integrin binding IPI
IPI: 通过物理相互作用推断
12473654 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11279249 GOA
enables vinculin binding IPI
IPI: 通过物理相互作用推断
15070891 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IMP
IMP: 通过突变表型推断
26923917 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
15070891 GOA
located in focal adhesion IMP
IMP: 通过突变表型推断
26923917 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TLN1 蛋白结构

FERM_N

FERM_N: FERM N-terminal domain (90 - 199)

FERM_M

FERM_M: FERM central domain (204 - 313)

IRS

IRS: PTB domain (IRS-1 type) (324 - 397)

Talin_middle

Talin_middle: Talin, middle domain (491 - 652)

VBS

VBS: Vinculin Binding Site (1234 - 1350)

VBS

VBS: Vinculin Binding Site (1849 - 1973)

I_LWEQ

I_LWEQ: I/LWEQ domain (2385 - 2531)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2541 a.a.
蛋白主名 其他名称

talin-1

TLN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TLN1 Q9Y490 RET Homo sapiens P07949
Phage Display
39009827
种属内
TLN1 Q9Y490 EGFR Homo sapiens P00533
Protein Array
16273093
种属内
TLN1 Q9Y490 ERBB2 Homo sapiens P04626
Protein Array
16273093
种属内
TLN1 Q9Y490 ITGB3 Homo sapiens P05106
ELISA
16546176
种属内
TLN1 Q9Y490 ITGB1 Homo sapiens P05556
Solid Phase Assay
11279249
种属内
TLN1 Q9Y490 PIP5K1C Homo sapiens O60331
FPS
35044719
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Capillary Leak Syndrome

Systemic Capillary Leak Syndrome

Clarkson Disease

Capillary Leak Syndrome With Monoclonal Gammopathy

Scls

Periodic Systemic Capillary Leak Syndrome

Capillary Hyperpermeability Syndrome

Idiopathic Capillary Leak Syndrome
Adenomyosis

Endometriosis Of Uterus

Endometriosis Interna

Endometriosis Of Myometrium

Endometriosis, Myometrium

Uterine Adenomyosis

Adenomyosis Uteri

Internal Endometriosis
Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency

Leukocyte Adhesion Deficiency 1

LAD1

Lad

Lymphocyte Function-Associated Antigen 1 Immunodeficiency

Leukocyte Adhesion Deficiency Type I

Leukocyte Adhesion Deficiency Type 1

Linear Iga Bullous Dermatosis

Linear Iga Dermatosis

Leukocyte-Adhesion Deficiency Syndrome

Lfa1 Immunodeficiency

Congenital Leukocyte Adherence Deficiency

Lad-I

Linear Iga Disease

Leukocyte Adhesion Deficiency Syndrome

Lad 1

Lfa 1 Immunodeficiency

Linear Immunoglobulin A Dermatosis

Leucocyte Adhesion Deficiency Type 1

Leukocyte Adhesion Molecule Deficiency Type 1
Leukocyte Adhesion Deficiency, Type Iii

Leukocyte Adhesion Deficiency 3

LAD3

Leukocyte Adhesion Deficiency 1 Variant

Lad1v

Integrin Activation Deficiency Disease

Iadd

Leukocyte Adhesion Deficiency Type Iii

Lad1 Variant

Lad-1 Variant

Lad-Iii

Leukocyte Adhesion Deficiency-1 Variant

Leukocyte Adhesion Deficiency Type 1
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14574 TLN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TLN1 VGNC VGNC:35897
Canis familiaris TLN1 VGNC VGNC:47401
Felis catus TLN1 VGNC VGNC:66215
Mus musculus TLN1 MGD MGI:1099832
Macaca mulatta TLN1 VGNC VGNC:78371
Rattus norvegicus TLN1 RGD RGD:1306247
Others TLN1 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z