2. Gene
  3. TMPO - thymopoietin Gene

TMPO - thymopoietin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胸腺生成素

种属: Homo sapiens

同用名: TP; LAP2; CMD1T; LEMD4; PRO0868

基因 ID: 7112 | 基因类型: protein coding

关于 TMPO

Cytogenetic location: 12q23.1 Genomic coordinates (GRCh38): 12:98,515,573-98,550,351 (from NCBI)

This gene has 13 transcripts (splice variants), 280 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 23.3), bone marrow (RPKM 19.4) and 25 other tissues.

功能概要

通过选择性剪接，该基因编码了几个不同的 LEM 结构域，其中包含蛋白质亚型。 LEM 结构域蛋白包括内核膜和核内蛋白，参与多种细胞功能，包括基因表达、染色质组织以及复制和细胞周期控制。编码的 alpha 异构体在细胞核中广泛扩散并包含核纤层蛋白结合域，而 beta 和 gamma 异构体位于核膜并包含 HDAC3 相互作用域。当充当其他蛋白质的伴侣并调节转录时，不同的亚型可能会相互竞争。[RefSeq 提供，2019 年 8 月]

Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each Other when acting to chaperone Other proteins and regulate transcription. [provided by RefSeq, Aug 2019]

TMPO 基因产物(4)

mRNA Protein Name
NM_001032283.3 NP_001027454.1 thymopoietin isoform beta
NM_001032284.3 NP_001027455.1 thymopoietin isoform gamma
NM_001307975.2 NP_001294904.1 thymopoietin isoform delta
NM_003276.2 NP_003267.1 thymopoietin isoform alpha
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16247757 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
17284516 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
25468996 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17284516 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMPO 蛋白结构

Thymopoietin

Thymopoietin: Thymopoietin protein (2 - 50)

LEM

LEM: LEM domain (110 - 152)

LAP2alpha

LAP2alpha: Lamina-associated polypeptide 2 alpha (461 - 694)

  • 0
  • 200
  • 400
  • 600
  • 694 a.a.
蛋白主名 其他名称

thymopoietin

LEM domain containing 4

TMPO 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TMPO P42166 NEK7 Homo sapiens Q8TDX7
Anti Tag CoIP
32707033
种属内
TMPO P42166 LMNA Homo sapiens P02545
Pull Down
16247757
种属内
TMPO P42167 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
种属内
TMPO P42167 STOM Homo sapiens P27105
Y2H Array
32296183
种属内
TMPO P42167 KLHL6 Homo sapiens Q8WZ60
Validated Y2H
32296183
种属内
TMPO P42167 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
种属内
TMPO P42167 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
种属内
TMPO P42167 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TMPO 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71361 Thymopoietin Protein, Human (His) P42167 (M1-E187) ≥95%

关联疾病

疾病名称 别名
Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Emery-Dreifuss Muscular Dystrophy

Edmd

Emery-Dreifuss Syndrome

Muscular Dystrophy, Emery-Dreifuss

Humeroperoneal Neuromuscular Disease

Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures

Scapuloperoneal Syndrome, X-Linked

Benign Scapuloperoneal Muscular Dystrophy With Early Contractures

Muscular Dystrophy, Emery-Dreifuss Type

Muscular Dystrophy Emery-Dreifuss

Dystrophy, Muscular, Emery-Dreifuss

Emd - [Emery-Dreifuss Muscular Dystrophy]
Bronchitis

Chronic Bronchitis

Acute Bronchitis

Bronchitis, Chronic

Acute Bronchitis And Bronchiolitis

Chest Cold

Chest Infection

Ci - Chest Infection

Recurrent Wheezy Bronchitis

Bronchitis Chronic

Lower Respiratory Tract Infection

Acute Lower Respiratory Tract Infection

Chronic Bronchitis Nos

Senile Bronchitis

Bronchitis Nos In Those Under L5 Years Of Age

Bronchitis Nos
Myasthenia Gravis

MG

Acquired Myasthenia

Autoimmune Myasthenia Gravis

Erb-Goldflam Disease

Mg - [Myasthenia Gravis]

Myasthenia Gravis Nos

Myasthenia
Dysentery

Infectious Diarrhea
Reynolds Syndrome

Primary Biliary Cirrhosis, Scleroderma, Raynaud Disease, And Telangiectasia

Primary Biliary Cirrhosis And Systemic Scleroderma

REYNS

Primary Biliary Cirrhosis Scleroderma Raynaud Disease And Telangiectasia
Herpes Zoster

Shingles

Zoster

Herpes Zona

Herpes Zoster Disease

Zona Zoster

Herpes Zoster Of Skin And Mucous Membranes

Zoster Nos

Zoster With Nervous System Involvement
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1

Arrhythmogenic Right Ventricular Dysplasia 1

Uhl Anomaly

Arrhythmogenic Right Ventricular Cardiomyopathy 1

Arvc1

ARVD1

Cardiomyopathy Right Ventricular Dilated

Dysplasia, Arrhythmogenic Right Ventricular, Type 1
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Neuromuscular Disease

Neuromuscular Diseases

Neuromuscular Disorders

Neuromuscular Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14762 TMPO Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TMPO RGD RGD:3875
Mus musculus TMPO MGD MGI:106920
Bos taurus TMPO VGNC VGNC:36138
Macaca mulatta TMPO VGNC VGNC:78574
Canis familiaris TMPO VGNC VGNC:47627
Felis catus TMPO VGNC VGNC:97665
Others TMPO NCBI
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