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  2. TPSAB1 - tryptase alpha/beta 1 Gene

TPSAB1 - tryptase alpha/beta 1 Gene

中文名称:类胰蛋白酶 α/β 1

种属: Homo sapiens

同用名: TPS1; TPS2; TPSB1; TPSB2; Tryptase-2

基因 ID: 7177 | 基因类型: protein coding

关于 TPSAB1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,240,705-1,242,554 (from NCBI)

This gene has 5 transcripts (splice variants), 841 orthologues and 3 paralogues. Biased expression in gall bladder (RPKM 111.8), lung (RPKM 108.7) and 13 other tissues.

功能概要

类胰蛋白酶包含胰蛋白酶样丝氨酸蛋白酶家族,即肽酶家族 S1。类胰蛋白酶仅作为肝素稳定的四聚体具有酶促活性,并且它们对所有已知的内源性蛋白酶抑制剂具有抗性。几个类胰蛋白酶基因聚集在染色体 16p13.3 上。这些基因具有几个不同的特征。它们具有高度保守的 3' UTR,并在 5' 侧翼和 3' UTR 处包含串联重复序列,这些序列被认为在调节 mRNA 稳定性方面发挥作用。这些基因在启动子 Met 密码子的上游有一个内含子,它将转录起始位点与蛋白质编码序列分开。此功能是类胰蛋白酶的特征,但在其他基因中并不常见。该基因的等位基因表现出异常数量的序列变异,因此等位基因曾被认为代表两个独立的基因,α 和β 1。β 类胰蛋白酶似乎是肥大细胞中表达的主要同工酶;而在嗜碱性粒细胞中,α类胰蛋白酶占主导地位。类胰蛋白酶被认为是哮喘和其他过敏性和炎症性疾病发病机制中的介质。[RefSeq 提供,2008 年 7 月]

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in Other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and Other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

TPSAB1 基因产物(1)

mRNA Protein Name
NM_003294.4 NP_003285.2 tryptase alpha/beta-1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
29661938 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in extracellular matrix disassembly IDA
IDA: 通过直接分析推断
27068509 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TPSAB1 蛋白结构

Trypsin

Trypsin: Trypsin (31 - 267)

  • 0
  • 100
  • 200
  • 275 a.a.
蛋白主名 其他名称

tryptase alpha/beta-1

Tryptase II

TPSAB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TPSAB1 Q15661 P0C6X7-PRO_0000037309 Human SARS coronavirus P0C6X7-PRO_0000037309 22046132
种属内
TPSAB1 Q15661 TPSAB1 Homo sapiens Q15661
GMS
29661938
种属内
TPSAB1 Q15661 TPSAB1 Homo sapiens Q15661 29661938
种属内
TPSAB1 Q15661 PIK3R1 Homo sapiens P27986 17474147
种属内
TPSAB1 Q15661 P0C6X7-PRO_0000037318 Human SARS coronavirus P0C6X7-PRO_0000037318 22046132
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TPSAB1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71125 TPSB2 Protein, Human (HEK293, His) AAH29356.1 (A19-P275) ≥95%

TPSAB1 抗体

目录号 产品名 应用 反应物种
HY-P81386 TPSB2 Antibody (YA1131) IHC-P Human
HY-P81788 Mast Cell Tryptase Antibody (YA1533) WB, IHC-P, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Mastocytosis

Mast Cell Disease

Mast Cell Hyperplasia

Urticaria Pigmentosa

Malignant Mastocytoma

Malignant Mast Cell Tumours

Malignant Mastocytosis

Systemic Mastocytosis

Systemic Mast Cell Disease

Systemic Tissue Mast Cell Disease

Mastocytosis, Systemic

Smcd - Systemic Mast Cell Disease

Smcd

Mast Cell Disease, Systemic

Systemic Mast-Cell Disease

Systemic Mastocytoses

Mastocytosis Systemic

Corneal Dystrophy, Subepithelial Mucinous

Smcd - [Systemic Mast Cell Disease]

Hereditary Alpha Tryptasemia Syndrome
Mastocytosis, Cutaneous

Urticaria Pigmentosa

Cutaneous Mastocytosis

Diffuse Cutaneous Mastocytosis

Maculopapular Cutaneous Mastocytosis

Mastocytosis, Diffuse Cutaneous

MASTC

Mastocytosis, Maculopapular Cutaneous

Mastocytosis, Systemic, Somatic

Mastocytoma

Dcm

Diffuse Cutaneous Maculopapulous Mastocytosis

Up/Mpcm

Cm

Mastocytosis, Systemic

MASTSYS

Mast Cell Disease

Mast-Cell Disease

Mast Cell Leukemia

Mastocytosis, Indolent

Mastocytosis With Associated Hematologic Disorder

Mast Cell Neoplasm

Benign Mastocytoma

Chronic Pain
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory

Candida Glabrata

Torulopsis Glabrata

Chlorhexidine Allergy
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Solitary Mastocytoma Of The Skin

Cutaneous Solitary Mastocytoma

Skin Mastocytoma

Solitary Mastocytoma

Solitary Mastocytoma Of Skin

Mastocytoma, Skin

Physical Urticaria

Symptomatic Dermographism

Polyposis Syndrome, Hereditary Mixed, 2

HMPS2

Hereditary Mixed Polyposis Syndrome 2

Polyposis Syndrome, Mixed Hereditary 2

Polyposis Syndrome, Hereditary Mixed, Type 2

Postural Orthostatic Tachycardia Syndrome

Irritable Heart

Mitral Valve Prolapse Syndrome

Neurocirculatory Asthenia

Orthostatic Intolerance Due To Net Deficiency

Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency

Orhtostatic Intolerance

Postural Tachycardia Syndrome Due To Net Deficiency

Soldiers Heart

Gene Duplication Disease

Gene Duplication Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TPSAB1 RGD RGD:3066
Macaca fascicularis TPSAB1 NCBI