TPSAB1 - tryptase alpha/beta 1 Gene

中文名称：类胰蛋白酶 α/β 1

种属: Homo sapiens

同用名: TPS1; TPS2; TPSB1; TPSB2; Tryptase-2

基因 ID: 7177 | 基因类型: protein coding

关于 TPSAB1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,240,705-1,242,554 (from NCBI)

This gene has 5 transcripts (splice variants), 841 orthologues and 3 paralogues. Biased expression in gall bladder (RPKM 111.8), lung (RPKM 108.7) and 13 other tissues.

功能概要

类胰蛋白酶包含胰蛋白酶样丝氨酸蛋白酶家族，即肽酶家族 S1。类胰蛋白酶仅作为肝素稳定的四聚体具有酶促活性，并且它们对所有已知的内源性蛋白酶抑制剂具有抗性。几个类胰蛋白酶基因聚集在染色体 16p13.3 上。这些基因具有几个不同的特征。它们具有高度保守的 3' UTR，并在 5' 侧翼和 3' UTR 处包含串联重复序列，这些序列被认为在调节 mRNA 稳定性方面发挥作用。这些基因在启动子 Met 密码子的上游有一个内含子，它将转录起始位点与蛋白质编码序列分开。此功能是类胰蛋白酶的特征，但在其他基因中并不常见。该基因的等位基因表现出异常数量的序列变异，因此等位基因曾被认为代表两个独立的基因，α 和β 1。β 类胰蛋白酶似乎是肥大细胞中表达的主要同工酶；而在嗜碱性粒细胞中，α类胰蛋白酶占主导地位。类胰蛋白酶被认为是哮喘和其他过敏性和炎症性疾病发病机制中的介质。[RefSeq 提供，2008 年 7 月]

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in Other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and Other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

TPSAB1 基因产物(1)

mRNA	Protein	Name
NM_003294.4	NP_003285.2	tryptase alpha/beta-1 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	29661938	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17474147	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in extracellular matrix disassembly	IDA IDA: 通过直接分析推断	27068509	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPSAB1 蛋白结构

Trypsin

0
100
200
275 a.a.

蛋白主名

其他名称

tryptase alpha/beta-1

Tryptase II

TPSAB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TPSAB1	Q15661	P0C6X7-PRO_0000037309	Human SARS coronavirus	P0C6X7-PRO_0000037309	Lumier	22046132
种属内	TPSAB1	Q15661	TPSAB1	Homo sapiens	Q15661	GMS	29661938
种属内	TPSAB1	Q15661	TPSAB1	Homo sapiens	Q15661	Comigration in SDS	29661938
种属内	TPSAB1	Q15661	PIK3R1	Homo sapiens	P27986	Peptide Array	17474147
种属内	TPSAB1	Q15661	P0C6X7-PRO_0000037318	Human SARS coronavirus	P0C6X7-PRO_0000037318	Y2H Pooling	22046132

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TPSAB1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71125	TPSB2 Protein, Human (HEK293, His)	AAH29356.1 (A19-P275)	≥95%

TPSAB1 抗体

目录号	产品名	应用	反应物种
HY-P81386	TPSB2 Antibody (YA1131)	IHC-P	Human
HY-P81788	Mast Cell Tryptase Antibody (YA1533)	WB, IHC-P, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Mastocytosis

Mast Cell Disease	Mast Cell Hyperplasia
Urticaria Pigmentosa	Malignant Mastocytoma
Malignant Mast Cell Tumours	Malignant Mastocytosis

Systemic Mastocytosis

Systemic Mast Cell Disease	Systemic Tissue Mast Cell Disease
Mastocytosis, Systemic	Smcd - Systemic Mast Cell Disease
Smcd	Mast Cell Disease, Systemic
Systemic Mast-Cell Disease	Systemic Mastocytoses
Mastocytosis Systemic	Corneal Dystrophy, Subepithelial Mucinous
Smcd - [Systemic Mast Cell Disease]

Hereditary Alpha Tryptasemia Syndrome

Mastocytosis, Cutaneous

Urticaria Pigmentosa	Cutaneous Mastocytosis
Diffuse Cutaneous Mastocytosis	Maculopapular Cutaneous Mastocytosis
Mastocytosis, Diffuse Cutaneous	MASTC
Mastocytosis, Maculopapular Cutaneous	Mastocytosis, Systemic, Somatic
Mastocytoma	Dcm
Diffuse Cutaneous Maculopapulous Mastocytosis	Up/Mpcm
Cm	Mastocytosis, Systemic
MASTSYS	Mast Cell Disease
Mast-Cell Disease	Mast Cell Leukemia
Mastocytosis, Indolent	Mastocytosis With Associated Hematologic Disorder
Mast Cell Neoplasm	Benign Mastocytoma

Chronic Pain

Vibratory Urticaria

Vibratory Angioedema	Dermodistortive Urticaria
VBU	Ddu
Angioedema, Vibratory

Candida Glabrata

Torulopsis Glabrata

Chlorhexidine Allergy

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Solitary Mastocytoma Of The Skin

Cutaneous Solitary Mastocytoma	Skin Mastocytoma
Solitary Mastocytoma	Solitary Mastocytoma Of Skin
Mastocytoma, Skin

Physical Urticaria

Symptomatic Dermographism

Polyposis Syndrome, Hereditary Mixed, 2

HMPS2	Hereditary Mixed Polyposis Syndrome 2
Polyposis Syndrome, Mixed Hereditary 2	Polyposis Syndrome, Hereditary Mixed, Type 2

Postural Orthostatic Tachycardia Syndrome

Irritable Heart	Mitral Valve Prolapse Syndrome
Neurocirculatory Asthenia	Orthostatic Intolerance Due To Net Deficiency
Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency	Orhtostatic Intolerance
Postural Tachycardia Syndrome Due To Net Deficiency	Soldiers Heart

Gene Duplication Disease

Gene Duplication Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14952	TPSAB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990533	Anti-TPSAB1 Antibody		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TPSAB1	RGD	RGD:3066
Macaca fascicularis	TPSAB1	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TPSAB1 - tryptase alpha/beta 1 Gene

关于 TPSAB1

功能概要

TPSAB1 基因产物(1)

TPSAB1 蛋白结构

TPSAB1 蛋白互作信息

重组 TPSAB1 蛋白

TPSAB1 抗体

关联疾病

直系同源

热门区域

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TPSAB1 - tryptase alpha/beta 1 Gene

关于 TPSAB1

功能概要

TPSAB1 基因产物(1)

TPSAB1 蛋白结构

TPSAB1 蛋白互作信息

重组 TPSAB1 蛋白

TPSAB1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z