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  2. MPPED2 - metallophosphoesterase domain containing 2 Gene

MPPED2 - metallophosphoesterase domain containing 2 Gene

中文名称:含金属磷酸酯酶结构域 2

种属: Homo sapiens

同用名: 239FB; C11orf8

基因 ID: 744 | 基因类型: protein coding

关于 MPPED2

Cytogenetic location: 11p14.1 Genomic coordinates (GRCh38): 11:30,384,079-30,586,993 (from NCBI)

This gene has 8 transcripts (splice variants), 135 orthologues and 1 paralogue. Biased expression in thyroid (RPKM 4.7), prostate (RPKM 2.5) and 11 other tissues.

功能概要

该基因可能编码金属磷酸酯酶。编码的蛋白质可能在大脑发育中发挥作用。已经描述了选择性剪接的转录物变体。[RefSeq 提供,2009 年 2 月]

This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

MPPED2 基因产物(7)

mRNA Protein Name
NM_001145399.3 NP_001138871.1 metallophosphoesterase MPPED2 isoform 2
NM_001377952.1 NP_001364881.1 metallophosphoesterase MPPED2 isoform 1
NM_001377953.1 NP_001364882.1 metallophosphoesterase MPPED2 isoform 1
NM_001377954.1 NP_001364883.1 metallophosphoesterase MPPED2 isoform 1
NM_001377955.1 NP_001364884.1 metallophosphoesterase MPPED2 isoform 1
NM_001377956.1 NP_001364885.1 metallophosphoesterase MPPED2 isoform 2
NM_001584.3 NP_001575.1 metallophosphoesterase MPPED2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19060904 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MPPED2 蛋白结构

Metallophos

Metallophos: Calcineurin-like phosphoesterase (74 - 255)

  • 0
  • 100
  • 200
  • 294 a.a.
蛋白主名 其他名称

metallophosphoesterase MPPED2

fetal brain protein 239

MPPED2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MPPED2 Q15777 CAGE1 Homo sapiens Q8TC20
Y2H Array
25416956
种属内
MPPED2 Q15777 CAGE1 Homo sapiens Q8TC20
Y2H Prey Pooling
25416956
种属内
MPPED2 Q15777 FAM72A Homo sapiens Q5TYM5
Validated Y2H
25416956
种属内
MPPED2 Q15777 RIBC1 Homo sapiens Q8N443
Validated Y2H
32296183
种属内
MPPED2 Q15777 RIBC1 Homo sapiens Q8N443
Y2H Array
32296183
种属内
MPPED2 Q15777 RIBC1 Homo sapiens Q8N443
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 NUP93 Homo sapiens Q8N1F7
Validated Y2H
32296183
种属内
MPPED2 Q15777 NUP93 Homo sapiens Q8N1F7
Y2H Array
32296183
种属内
MPPED2 Q15777 NUP93 Homo sapiens Q8N1F7
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 HOOK2 Homo sapiens Q96ED9-2
Validated Y2H
32296183
种属内
MPPED2 Q15777 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
种属内
MPPED2 Q15777 CAGE1 Homo sapiens Q8TC20-4
Y2H Array
32296183
种属内
MPPED2 Q15777 CAGE1 Homo sapiens Q8TC20-4
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 CAGE1 Homo sapiens Q8TC20-4
Validated Y2H
32296183
种属内
MPPED2 Q15777 MBD3L1 Homo sapiens Q8WWY6
Validated Y2H
32296183
种属内
MPPED2 Q15777 MBD3L1 Homo sapiens Q8WWY6
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 MBD3L1 Homo sapiens Q8WWY6
Y2H Array
32296183
种属内
MPPED2 Q15777 BEX4 Homo sapiens Q9NWD9
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 BEX4 Homo sapiens Q9NWD9
Validated Y2H
32296183
种属内
MPPED2 Q15777 BEX4 Homo sapiens Q9NWD9
Y2H Array
32296183
种属内
MPPED2 Q15777 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
种属内
MPPED2 Q15777 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 TRIP13 Homo sapiens Q15645
Y2H Pooling
19060904
种属内
MPPED2 Q15777 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
种属内
MPPED2 Q15777 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
25416956
种属内
MPPED2 Q15777 TRIP13 Homo sapiens Q15645
Validated Y2H
25416956
种属内
MPPED2 Q15777 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 TRIP13 Homo sapiens Q15645
Y2H Array
19060904
种属内
MPPED2 Q15777 POMP Homo sapiens Q9Y244
Y2H Array
32296183
种属内
MPPED2 Q15777 POMP Homo sapiens Q9Y244
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 POMP Homo sapiens Q9Y244
Validated Y2H
32296183
种属内
MPPED2 Q15777 RXRG Homo sapiens P48443
Y2H Array
32296183
种属内
MPPED2 Q15777 RXRG Homo sapiens P48443
Y2H Prey Pooling
32296183
种属内
MPPED2 Q15777 RXRG Homo sapiens P48443
Validated Y2H
25416956
种属内
MPPED2 Q15777 RXRG Homo sapiens P48443
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

Wagr Syndrome

11p Partial Monosomy Syndrome

Chromosome 11p13 Deletion Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome

11p Deletion Syndrome

Chromosome 11p Deletion Syndrome

Wagr Complex

Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome

Deletion 11p13

WAGR

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome

Chromosome 11p Deletion

11p Deletion

11p Monosomy

Deletion 11p

Monosomy 11p

Partial Monosomy 11p

Agr Triad

Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

Wagr Contiguous Gene Syndrome

Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome

Del(11)(P13)

Monosomy 11p13

Chromosome 11, Deletion 11p

Aniridia 1

Aniridia

Congenital Aniridia

AN1

An

Cataract With Late-Onset Corneal Dystrophy

Aplasia Of Iris

Absent Iris

Irideremia

Aniridia Ii, Formerly

An2, Formerly

An2

Aniridia Type Ii

Aniridia, Type 1

An-1

Absence Of Iris

Agenesis Of Iris

Congenital Absence Of Iris

Hereditary Aniridia

Sporadic Aniridia

Urofacial Syndrome 1

Urofacial Syndrome

Ochoa Syndrome

Hydronephrosis With Peculiar Facial Expression

Ufs

Inverted Smile And Occult Neuropathic Bladder

Partial Facial Palsy With Urinary Abnormalities

UFS1

Urofacial Ochoa'S Syndrome

Urofacial Syndrome Type 1

Facial Palsy, Partial, With Urinary Abnormalities

Hydronephrosis-Inverted Smile

Inverted Smile-Neurogenic Bladder

Hydronephrosis-Inverted Smile Syndrome

Inverted Smile-Neurogenic Bladder Syndrome

Partial Facial Palsy Partial With Urinary Abnormalities

Urologic Diseases

Iris Disease

Iris Diseases

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MPPED2 VGNC VGNC:43350
Macaca mulatta MPPED2 VGNC VGNC:74727
Rattus norvegicus MPPED2 RGD RGD:735060
Felis catus MPPED2 VGNC VGNC:63575
Bos taurus MPPED2 VGNC VGNC:31588
Mus musculus MPPED2 MGD MGI:1924265