2. Gene
  3. FMNL1 - formin like 1 Gene

FMNL1 - formin like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：形成样 1

种属: Homo sapiens

同用名: FMNL; FHOD4; KW-13; C17orf1; C17orf1B

基因 ID: 752 | 基因类型: protein coding

关于 FMNL1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,221,885-45,247,318 (from NCBI)

This gene has 11 transcripts (splice variants), 287 orthologues and 18 paralogues. Biased expression in bone marrow (RPKM 59.8), appendix (RPKM 26.8) and 11 other tissues.

功能概要

该基因编码与甲酸相关的蛋白质。 Formin 相关蛋白与形态发生、胞质分裂和细胞极性有关。已经描述了另一种剪接变体，但尚未确定其全长序列。[RefSeq 提供，2008 年 7 月]

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

FMNL1 基因产物(2)

mRNA Protein Name
NM_001411128.1 NP_001398057.1 formin-like protein 1 isoform 2
NM_005892.4 NP_005883.3 formin-like protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activating protein binding IDA
IDA: 通过直接分析推断
21148482 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21148482 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cortical actin cytoskeleton organization IMP
IMP: 通过突变表型推断
21834987 GOA
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
21834987 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FMNL1 蛋白结构

Drf_GBD

Drf_GBD: Diaphanous GTPase-binding Domain (29 - 155)

Drf_GBD

Drf_GBD: Diaphanous GTPase-binding Domain (223 - 281)

Drf_FH3

Drf_FH3: Diaphanous FH3 Domain (284 - 435)

FH2

FH2: Formin Homology 2 Domain (633 - 998)

  • 0
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  • 1000
  • 1100 a.a.
蛋白主名 其他名称

formin-like protein 1

CLL-associated antigen KW-13

FMNL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FMNL1 O95466 SRGAP2 Homo sapiens O75044
Anti Tag CoIP
21148482
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma
Cerebral Amyloid Angiopathy, Itm2b-Related, 2

Dementia, Familial Danish

Fdd

Familial Danish Dementia

Heredopathia Ophthalmootoencephalica

Hooe

Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis

Adan Amyloidosis

Itm2b-Related Cerebral Amyloid Angiopathy 2

Itm2b Amyloidosis

Familial Cerebral Amyloid Angiopathy

Itm2b-Related Amyloidosis

Itm2b-Related Cerebral Amyloid Angiopathy

Familial Dementia, Danish Type

Cerebral Amyloid Angiopathy, Itm2b-Related 2

CAA-ITM2B2

Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis

Dementia, Familial, Danish
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05002 FMNL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris FMNL1 VGNC VGNC:40914
Felis catus FMNL1 VGNC VGNC:62304
Macaca mulatta FMNL1 VGNC VGNC:72480
Rattus norvegicus FMNL1 RGD RGD:1311042
Mus musculus FMNL1 MGD MGI:1888994
Bos taurus FMNL1 VGNC VGNC:29046
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