TRIM25 - tripartite motif containing 25 Gene

中文名称：含三方基序 25

种属: Homo sapiens

同用名: EFP; Z147; RNF147; ZNF147

基因 ID: 7706 | 基因类型: protein coding

关于 TRIM25

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,887,909-56,914,049 (from NCBI)

This gene has 12 transcripts (splice variants), 125 orthologues and 80 paralogues. Ubiquitous expression in bone marrow (RPKM 21.8), skin (RPKM 15.8) and 25 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。该蛋白是一种 RNA 结合蛋白，作为泛素 E3 连接酶发挥作用，参与多种细胞过程，包括抗病毒先天免疫的调节。[RefSeq 提供，2021 年 9 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 Ligase and is involved in multiple cellular processes, including regulation of Antiviral innate immunity. [provided by RefSeq, Sep 2021]

TRIM25 基因产物(1)

mRNA	Protein	Name
NM_005082.5	NP_005073.2	E3 ubiquitin/ISG15 ligase TRIM25

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RIG-I binding	IPI IPI: 通过物理相互作用推断	23950712	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19454348	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	23077300	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	16352599	GOA
enables ubiquitin protein ligase activity	IMP IMP: 通过突变表型推断	24810856	GOA
enables ubiquitin-protein transferase activity	EXP EXP: 通过实验结果推断	17392790	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERAD pathway	IMP IMP: 通过突变表型推断	24810856	GOA
NOT involved in RIG-I signaling pathway	IMP IMP: 通过突变表型推断	31006531	GOA
involved in antiviral innate immune response	IDA IDA: 通过直接分析推断	17392790	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: 通过直接分析推断	17392790	GOA
involved in innate immune response	IDA IDA: 通过直接分析推断	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: 通过突变表型推断	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	23077300	GOA
involved in protein K48-linked ubiquitination	IDA IDA: 通过直接分析推断	36075446	GOA
involved in protein monoubiquitination	IMP IMP: 通过突变表型推断	24810856	GOA
involved in regulation of viral entry into host cell	IDA IDA: 通过直接分析推断	18248090	GOA
involved in response to estrogen	IDA IDA: 通过直接分析推断	22452784	GOA
involved in response to oxidative stress	IDA IDA: 通过直接分析推断	36075446	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	22452784	GOA
involved in viral release from host cell	IMP IMP: 通过突变表型推断	18248090	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	23950712	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	23950712	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM25 蛋白结构

zf-C3HC4_4

PRY

SPRY

0
100
200
300
400
500
630 a.a.

蛋白主名

其他名称

E3 ubiquitin/ISG15 ligase TRIM25

RING finger protein 147

TRIM25 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	TRIM25	Q14258	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34452305
种属间	TRIM25	Q14258	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34471099
种属间	TRIM25	Q14258	NSS	sfts virus hb29	A0A0B5AC19	Confocal	24478431
种属内	TRIM25	Q14258	RIGI	Homo sapiens	O95786	BiFC	24478431
种属内	TRIM25	Q14258	RIGI	Homo sapiens	O95786	Anti Tag CoIP	34452305
种属内	TRIM25	Q14258	RIGI	Homo sapiens	O95786	Anti Tag CoIP	34471099
种属内	TRIM25	Q14258	RIGI	Homo sapiens	O95786	Confocal	34471099
种属间	TRIM25	Q14258	NS	Influenza A virus	P03496	Anti Bait CoIP	19454348
种属间	TRIM25	Q14258	N	Middle East respiratory syndrome-related coronavirus	K9N4V7	Anti Tag CoIP	32295922

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Gingival Recession

Localized Gingival Recession	Gingival Recession, Localized
Minimal Gingival Recession	Moderate Gingival Recession
Severe Gingival Recession	Gingival Recession, Minimal
Gingival Recession, Severe	Atrophy Of Gums
Gum Atrophy	Gingival Atrophy

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Gingival Disease

Gingival Diseases	Gum Disease
Gingival Disorder	Gingivitis And Periodontal Diseases

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-162065	N6F11	Inducer	98.37%	否
HY-RS15030	TRIM25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TRIM25	VGNC	VGNC:47810
Felis catus	TRIM25	VGNC	VGNC:66531
Macaca mulatta	TRIM25	VGNC	VGNC:78847
Rattus norvegicus	TRIM25	RGD	RGD:1594396
Mus musculus	TRIM25	MGD	MGI:102749
Bos taurus	TRIM25	VGNC	VGNC:36322

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRIM25 - tripartite motif containing 25 Gene

关于 TRIM25

功能概要

TRIM25 基因产物(1)

TRIM25 蛋白结构

TRIM25 蛋白互作信息

关联疾病

直系同源

热门区域

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TRIM25 - tripartite motif containing 25 Gene

关于 TRIM25

功能概要

TRIM25 基因产物(1)

TRIM25 蛋白结构

TRIM25 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z