DAP3 - death associated protein 3 Gene

中文名称：死亡相关蛋白 3

种属: Homo sapiens

同用名: DAP-3; S29mt; MRPS29; MRP-S29; bMRP-10

关于 DAP3

功能概要

哺乳动物线粒体核糖体蛋白由核基因编码，有助于线粒体内的蛋白质合成。线粒体核糖体 (线粒体核糖体) 由一个小的 28S 亚基和一个大的 39S 亚基组成。与原核核糖体相比，它们估计有 75% 的蛋白质与 rRNA 组成，而原核核糖体的比例是相反的。哺乳动物 线粒体核糖体 和原核核糖体之间的另一个区别是后者包含 5S rRNA。在不同的物种中，构成核糖体的蛋白质在序列上有很大差异，有时在生化特性上也有很大差异，这使得序列同源性难以识别。该基因编码 28S 亚基蛋白，该蛋白也参与由肿瘤坏死因子-α、Fas 配体和 γ 干扰素启动的细胞凋亡途径。这种蛋白质可能与 ATP/GTP 结合，并且可能是线粒体蛋白 S27 的功能伙伴。已经为该基因发现了编码不同亚型的多个选择性剪接的转录物变体。对应于该基因的假基因位于染色体 1q 和 2q 上。[RefSeq 提供，2010 年 12 月]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]