COLEC11 - collectin subfamily member 11 Gene

中文名称：收集素亚科成员 11

种属: Homo sapiens

同用名: 3MC2; CLK1; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb

基因 ID: 78989 | 基因类型: protein coding

关于 COLEC11

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:3,595,112-3,644,644 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in gall bladder (RPKM 20.2), liver (RPKM 13.5) and 9 other tissues.

功能概要

该基因编码 C 型凝集素的聚集素家族成员，该凝集素具有胶原样序列和碳水化合物识别域。收集素是分泌性蛋白质，通过与微生物上的碳水化合物抗原结合，促进其识别和清除，在先天免疫系统中发挥重要作用。编码的蛋白质与多种糖结合，优先选择岩藻糖和甘露糖。该基因的突变是 3MC 综合征 2 的一个原因。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on Microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

COLEC11 基因产物(10)

mRNA	Protein	Name
NM_001255982.2	NP_001242911.1	collectin-11 isoform c precursor
NM_001255983.2	NP_001242912.1	collectin-11 isoform d precursor
NM_001255984.2	NP_001242913.1	collectin-11 isoform e precursor
NM_001255985.1	NP_001242914.1	collectin-11 isoform f precursor
NM_001255986.1	NP_001242915.1	collectin-11 isoform g
NM_001255987.1	NP_001242916.1	collectin-11 isoform h
NM_001255988.1	NP_001242917.1	collectin-11 isoform i
NM_001255989.1	NP_001242918.1	collectin-11 isoform j
NM_024027.5	NP_076932.1	collectin-11 isoform a precursor
NM_199235.3	NP_954705.1	collectin-11 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables D-mannose binding	IDA IDA: 通过直接分析推断	20956340	GOA
enables DNA binding	IDA IDA: 通过直接分析推断	20956340	GOA
enables calcium ion binding	IDA IDA: 通过直接分析推断	25912189	GOA
enables calcium-dependent carbohydrate binding	IDA IDA: 通过直接分析推断	25912189	GOA
enables fucose binding	IDA IDA: 通过直接分析推断	20956340	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	20956340	GOA
enables oligosaccharide binding	IDA IDA: 通过直接分析推断	25912189	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20956340	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral response	IDA IDA: 通过直接分析推断	20956340	GOA
involved in complement activation	IDA IDA: 通过直接分析推断	23954398	GOA
involved in complement activation, lectin pathway	IDA IDA: 通过直接分析推断	24174618	GOA
involved in complement activation, lectin pathway	IMP IMP: 通过突变表型推断	25912189	GOA
involved in positive regulation of opsonization	IDA IDA: 通过直接分析推断	24174618	GOA
involved in proteolysis	IDA IDA: 通过直接分析推断	24174618	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	25912189	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COLEC11 蛋白结构

Collagen

Lectin_C

0
100
200
271 a.a.

蛋白主名

其他名称

collectin-11

Collectin K1

COLEC11 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	COLEC11	Q9BWP8	MASP1	Homo sapiens	P48740-1	ELISA	24174618
种属内	COLEC11	Q9BWP8	COLEC10	Homo sapiens	Q9Y6Z7	ELISA	24174618
种属内	COLEC11	Q9BWP8	MASP1	Homo sapiens	P48740	ELISA	20956340
种属内	COLEC11	Q9BWP8	Q9BWP8-PRO_0000315044	Homo sapiens	Q9BWP8-PRO_0000315044	Anti Bait CoIP	24174618
种属内	COLEC11	Q9BWP8	MASP2	Homo sapiens	O00187	ELISA	24174618
种属内	COLEC11	Q9BWP8	COLEC11	Homo sapiens	Q9BWP8	GMS	20956340
种属内	COLEC11	Q9BWP8	MASP1	Homo sapiens	P48740-2	ELISA	24174618
种属内	COLEC11	Q9BWP8	MASP1	Homo sapiens	P48740	Anti Bait CoIP	24174618
种属内	COLEC11	Q9BWP8	COLEC11	Homo sapiens	Q9BWP8	Ion Exchange Chrom	24174618
种属内	COLEC11	Q9BWP8	Q9Y6Z7-PRO_0000314233	Homo sapiens	Q9Y6Z7-PRO_0000314233	Anti Bait CoIP	24174618
种属内	COLEC11	Q9BWP8	Q9BWP8-PRO_0000315044	Homo sapiens	Q9BWP8-PRO_0000315044	Ion Exchange Chrom	24174618
种属内	COLEC11	Q9BWP8	COLEC11	Homo sapiens	Q9BWP8	Comig Non-Denat Gel	20956340
种属内	COLEC11	Q9BWP8	Q9Y6Z7-PRO_0000314233	Homo sapiens	Q9Y6Z7-PRO_0000314233	Ion Exchange Chrom	24174618

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 COLEC11 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70100	Collectin-11/CL-K1 Protein, Human (HEK293, His)	Q9BWP8 (Q26-M271)	≥95%

关联疾病

疾病名称

别名

3mc Syndrome 2

3MC2	Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Carnevale Syndrome	Carnevale Syndrome, Formerly
Carnevale Krajewska Fischetto Syndrome	3mc Syndrome, Type 2

3mc Syndrome

Craniofacial-Ulnar-Renal Syndrome	Malpuech Facial Clefting Syndrome
Oculopalatoskeletal Syndrome	Carnevale Syndrome
Michels Syndrome	Malpuech-Michels-Mingarelli-Carnevale Syndrome
Carnevale-Krajewska-Fischetto Syndrome	Craniosynostosis With Lid Anomalies
Malpuech Syndrome	Mingarelli Syndrome
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia	Ptosis-Strabismus-Rectus Abdominis Diastasis

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

3mc Syndrome 1

Oculopalatoskeletal Syndrome	3MC1
Craniosynostosis With Lid Anomalies	Michels Syndrome, Formerly
Michels Syndrome	3mc Syndrome, Type 1

Blepharophimosis

Properdin Deficiency, X-Linked

Properdin Deficiency	PFD
CFPD	Properdin P Factor Deficiency
Complement Factor Properdin Deficiency	X-Linked Properdin Deficiency
Properdin Deficiency, Type I	Properdin Deficiency, Type 1
Properdin Deficiency Disease

Van Maldergem Syndrome 1

Cerebrofacioarticular Syndrome	VMLDS1
Van Maldergem Syndrome	Cerebro-Facio-Articular Syndrome
Van Maldergem Wetzburger Verloes Syndrome

Radioulnar Synostosis

Radio-Ulnar Synostosis Type 1

Coffin-Siris Syndrome 9

Mrd27	CSS9
Mental Retardation, Autosomal Dominant 27	Autosomal Dominant Mental Retardation 27
Autosomal Dominant Non-Syndromic Intellectual Disability 27	Coffin-Siris Syndrome, Type 9

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Urinary Schistosomiasis

Schistosoma Haematobium Infection	Schistosoma Hematobium Infection
Schistosomiasis Due To Schistosoma Haematobium	Bladder Schistosomiasis
Cystitis With Bilharziasis	Schistosoma Haematobium
Schistosoma Hematobium Infectious Disease	Schistosomiasis Of Bladder
Vesical Schistosomiasis	Schistosomiasis Urinary
Schistosomiasis Haematobia	Genitourinary Bilharziasis
Genitourinary Tract Schistosomiasis	Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis]
Haematochyluria In Schistosomiasis	Infection Due To Schistosoma Matthei

Angioedema, Hereditary, 1

Hereditary Angioedema Type I	Hereditary Angioneurotic Edema
Hane	C1 Esterase Inhibitor Deficiency
Angioedema, Hereditary, 1 And 2	HAE1
Angioneurotic Edema, Hereditary	Angioedema, Hereditary, Type I
Hereditary Angioedema Type 2	Hae 2
Hae-Ii	Hereditary Angioneurotic Edema Type 2
Angioedema, Hereditary	HAE
Angioedema, Hereditary, Types I And Ii	Hereditary Angioedema, Type Ii
Angioedema, Hereditary, Type 1	Angioedemas, Hereditary
Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii

Hypertelorism

Eyes Wide Apart	Eyes Widely Set
Hypertelorism Of Orbit	Ocular Hypertelorism
Orbital Separation Excessive

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Orofacial Cleft

Cleft, Orofacial

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03004	COLEC11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	COLEC11	RGD	RGD:1309678
Bos taurus	COLEC11	VGNC	VGNC:27578
Canis familiaris	COLEC11	VGNC	VGNC:39489
Macaca mulatta	COLEC11	VGNC	VGNC:71194
Felis catus	COLEC11	VGNC	VGNC:61072
Mus musculus	COLEC11	MGD	MGI:1918943
Others	COLEC11	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

COLEC11 - collectin subfamily member 11 Gene

关于 COLEC11

功能概要

COLEC11 基因产物(10)

COLEC11 蛋白结构

COLEC11 蛋白互作信息

重组 COLEC11 蛋白

关联疾病

直系同源

热门区域

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COLEC11 - collectin subfamily member 11 Gene

关于 COLEC11

功能概要

COLEC11 基因产物(10)

COLEC11 蛋白结构

COLEC11 蛋白互作信息

重组 COLEC11 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z