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  3. CYREN - cell cycle regulator of NHEJ Gene

CYREN - cell cycle regulator of NHEJ Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NHEJ 细胞周期调节因子

种属: Homo sapiens

同用名: MRI; MRI-2; C7orf49

基因 ID: 78996 | 基因类型: protein coding

关于 CYREN

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,092,303-135,172,469 (from NCBI)

This gene has 14 transcripts (splice variants) and 96 orthologues. Ubiquitous expression in lung (RPKM 6.0), spleen (RPKM 6.0) and 25 other tissues.

功能概要

参与非同源末端连接双链断裂修复和非同源末端连接双链断裂修复的负调控。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Involved in double-strand break repair via nonhomologous end joining and negative regulation of double-strand break repair via nonhomologous end joining. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CYREN 基因产物(11)

mRNA Protein Name
NM_001243749.2 NP_001230678.1 cell cycle regulator of non-homologous end joining isoform 2
NM_001243751.2 NP_001230680.1 cell cycle regulator of non-homologous end joining isoform 2
NM_001243752.2 NP_001230681.1 cell cycle regulator of non-homologous end joining isoform 2
NM_001243753.2 NP_001230682.1 cell cycle regulator of non-homologous end joining isoform 2
NM_001243754.2 NP_001230683.1 cell cycle regulator of non-homologous end joining isoform 3
NM_001243755.2 NP_001230684.1 cell cycle regulator of non-homologous end joining isoform 3
NM_001305629.2 NP_001292558.1 cell cycle regulator of non-homologous end joining isoform 4
NM_001305630.2 NP_001292559.1 cell cycle regulator of non-homologous end joining isoform 5
NM_001363329.2 NP_001350258.1 cell cycle regulator of non-homologous end joining isoform 1
NM_001363330.2 NP_001350259.1 cell cycle regulator of non-homologous end joining isoform 1
NM_024033.4 NP_076938.2 cell cycle regulator of non-homologous end joining isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24610814 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in double-strand break repair via nonhomologous end joining IDA
IDA: 通过直接分析推断
24610814 GOA
involved in negative regulation of double-strand break repair via nonhomologous end joining IDA
IDA: 通过直接分析推断
28959974 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
24610814 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24610814 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CYREN 蛋白结构

MRI

MRI: Modulator of retrovirus infection (52 - 157)

  • 0
  • 100
  • 157 a.a.
蛋白主名 其他名称

cell cycle regulator of non-homologous end joining

modulator of retrovirus infection homolog

CYREN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CYREN Q9BWK5 MKLN1 Homo sapiens Q9UL63
Validated Y2H
32296183
种属内
CYREN Q9BWK5 ERCC6L2 Homo sapiens Q5T890
Y2H Array
32296183
种属内
CYREN Q9BWK5 ERCC6L2 Homo sapiens Q5T890
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Petrositis

Acute Petrositis

Chronic Petrositis

Inflammation Of Petrous Bone

Osteitis Of Petrous Bone

Osteomyelitis Of Petrous Bone
Epilepsy, Familial Temporal Lobe, 3

Epilepsy, Familial Mesial Temporal Lobe

Fmtle

Familial Temporal Lobe Epilepsy 3

ETL3

Familial Mesial Temporal Lobe Epilepsy
Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064
Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03490 CYREN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CYREN VGNC VGNC:59049
Macaca mulatta CYREN VGNC VGNC:81301
Rattus norvegicus CYREN RGD RGD:1563238
Bos taurus CYREN VGNC VGNC:52721
Mus musculus CYREN MGD MGI:1925662
Felis catus CYREN VGNC VGNC:102031
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