2. Gene
  3. PDCL3 - phosducin like 3 Gene

PDCL3 - phosducin like 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷导蛋白样 3

种属: Homo sapiens

同用名: VIAF; PHLP3; VIAF1; HTPHLP; PHLP2A

基因 ID: 79031 | 基因类型: protein coding

关于 PDCL3

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:100,562,993-100,576,739 (from NCBI)

This gene has 3 transcripts (splice variants), 222 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 9.1), esophagus (RPKM 8.2) and 25 other tissues.

功能概要

该基因编码 phosducin 样蛋白家族的成员，并且是异源三聚体 G 蛋白的推定调节剂。该蛋白质与 phosducin 具有广泛的氨基酸序列同源性。已显示 phosducin 样蛋白家族的成员与 G 蛋白的 β-γ 亚基结合。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]

PDCL3 基因产物(1)

mRNA Protein Name
NM_024065.5 NP_076970.1 phosducin-like protein 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15371430 GOA
enables protein folding chaperone IMP
IMP: 通过突变表型推断
26059764 GOA
enables protein folding chaperone IPI
IPI: 通过物理相互作用推断
23792958 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
17429077 GOA
involved in angiogenesis IMP
IMP: 通过突变表型推断
26059764 GOA
involved in chaperone-mediated protein folding IMP
IMP: 通过突变表型推断
26059764 GOA
involved in negative regulation of chaperone-mediated protein folding IMP
IMP: 通过突变表型推断
17429077 GOA
acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
23792958 GOA
acts upstream of or within positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
23792958 GOA
acts upstream of or within positive regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
23792958 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
26059764 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
26059764 GOA
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
23792958 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15371430 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
26059764 GOA
located in perinucleolar compartment IDA
IDA: 通过直接分析推断
26059764 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDCL3 蛋白结构

Phosducin

Phosducin: Phosducin (32 - 180)

  • 0
  • 100
  • 200
  • 239 a.a.
蛋白主名 其他名称

phosducin-like protein 3

IAP-associated factor VIAF1

PDCL3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDCL3 Q9H2J4 ACTRT3 Homo sapiens Q9BYD9
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome

Berdon Syndrome

MMIHS

Megacystis Microcolon Intestinal Hypoperistalsis Syndrome

Megacystis, Microcolon, Hypoperistalsis Syndrome

Visceral Myopathy

Mmih Syndrome

Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome

MMIHS1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih

Mmhs
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10198 PDCL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PDCL3 VGNC VGNC:44344
Rattus norvegicus PDCL3 RGD RGD:1309663
Mus musculus PDCL3 MGD MGI:1916083
Bos taurus PDCL3 VGNC VGNC:32667
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