1. Gene
  2. MMP28 - matrix metallopeptidase 28 Gene

MMP28 - matrix metallopeptidase 28 Gene

中文名称:基质金属肽酶 28

种属: Homo sapiens

同用名: MM28; MMP25; MMP-25; MMP-28; EPILYSIN

基因 ID: 79148 | 基因类型: protein coding

关于 MMP28

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,756,249-35,795,641 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 206 orthologues and 23 paralogues. Broad expression in fat (RPKM 8.8), skin (RPKM 8.6) and 18 other tissues.

功能概要

基质金属蛋白酶 (MMP) 家族的蛋白质参与正常生理过程 (如胚胎发育、生殖和组织重塑) 和疾病过程 (如哮喘和转移) 的细胞外基质分解。该基因编码一种降解酪蛋白的分泌酶。其表达模式表明它在组织稳态和伤口修复中发挥作用。该基因的可变剪接导致多个转录变体。[RefSeq 提供,2014 年 4 月]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted Enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

MMP28 基因产物(3)

mRNA Protein Name
NM_001032278.3 NP_001027449.1 matrix metalloproteinase-28 isoform 3 precursor
NM_024302.5 NP_077278.1 matrix metalloproteinase-28 isoform 1 preproprotein
NM_032950.4 NP_116568.1 matrix metalloproteinase-28 isoform 2 preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21152186 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MMP28 蛋白结构

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (33 - 86)

  • 0
  • 100
  • 130 a.a.
蛋白主名 其他名称

matrix metalloproteinase-28

matrix metalloprotease MMP25

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MMP28 VGNC VGNC:43287
Macaca mulatta MMP28 VGNC VGNC:74755
Rattus norvegicus MMP28 RGD RGD:1311573
Mus musculus MMP28 MGD MGI:2153062
Bos taurus MMP28 VGNC VGNC:31528
Felis catus MMP28 VGNC VGNC:63539