PRRC2A - proline rich coiled-coil 2A Gene

中文名称：富脯氨酸的卷曲螺旋 2A

种属: Homo sapiens

同用名: G2; BAT2; D6S51; D6S51E

基因 ID: 7916 | 基因类型: protein coding

关于 PRRC2A

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,620,715-31,637,771 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 111 orthologues and 2 paralogues. Broad expression in testis (RPKM 81.0), ovary (RPKM 32.9) and 25 other tissues.

功能概要

一组基因 BAT1-BAT5 位于 TNF α 和 TNF β 基因附近。这些基因都在人类主要组织相容性复合体 III 类区域内。该基因具有与胰岛素依赖性糖尿病 (IDDM) 的发病年龄相关的微卫星重复序列，并且可能被认为与 IDDM 发展过程中胰腺 β 细胞破坏的炎症过程有关。该基因也是类风湿性关节炎发展的候选基因。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2010 年 12 月]

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

PRRC2A 基因产物(2)

mRNA	Protein	Name
NM_004638.4	NP_004629.3	protein PRRC2A
NM_080686.3	NP_542417.2	protein PRRC2A

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16713569	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRRC2A 蛋白结构

BAT2_N

0
400
800
1200
1600
2000
2157 a.a.

蛋白主名

其他名称

protein PRRC2A

HLA-B-associated transcript 2

PRRC2A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRRC2A	P48634	JUN	Homo sapiens	P05412	TAP	20195357
种属内	PRRC2A	P48634	ATXN1	Homo sapiens	P54253	Y2H	16713569

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Benign Fibrous Mesothelioma

Fibrous Mesothelioma, Benign	Localized Benign Fibrous Mesothelioma
Solitary Fibrous Tumor, Pleural	Pleural Solitary Fibrous Tumor
Solitary Fibrous Tumor

Phonagnosia

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Diabetes Mellitus

Diabetes

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11236	PRRC2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PRRC2A	VGNC	VGNC:64390
Macaca mulatta	PRRC2A	VGNC	VGNC:83448
Bos taurus	PRRC2A	VGNC	VGNC:33404
Rattus norvegicus	PRRC2A	RGD	RGD:1303025
Canis familiaris	PRRC2A	VGNC	VGNC:45052
Mus musculus	PRRC2A	MGD	MGI:1915467

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRRC2A - proline rich coiled-coil 2A Gene

关于 PRRC2A

功能概要

PRRC2A 基因产物(2)

PRRC2A 蛋白结构

PRRC2A 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

PRRC2A - proline rich coiled-coil 2A Gene

关于 PRRC2A

功能概要

PRRC2A 基因产物(2)

PRRC2A 蛋白结构

PRRC2A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z