Hsf1 - heat shock transcription factor 1 Gene

中文名称：热休克转录因子 1

种属: Rattus norvegicus

关于 Hsf1

功能概要

该基因编码的蛋白可启动多种功能，包括 STAT 家族蛋白结合活性；启动子特异性染色质结合活性；和序列特异性单链 DNA 结合活性。参与多个过程，包括细胞对脂质的反应；大分子代谢过程的正向调控；和包涵体组装的调节。位于染色质；细胞质；和核。用于研究帕金森病；肌肉萎缩;和短暂性脑缺血。阿尔茨海默病的生物标志物；帕金森病；充血性心力衰竭;隐睾;和短暂性脑缺血。该基因的人类直系同源物与亨廷顿病有关。与人类 HSF1（热休克转录因子 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including STAT family protein binding activity; promoter-specific chromatin binding activity; and sequence-specific single stranded DNA binding activity. Involved in several processes, including cellular response to lipid; positive regulation of macromolecule metabolic process; and regulation of inclusion body assembly. Located in chromatin; cytoplasm; and nucleus. Used to study Parkinson's disease; muscular atrophy; and transient cerebral ischemia. Biomarker of Alzheimer's disease; Parkinson's disease; congestive heart failure; cryptorchidism; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]