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  3. Htr3a - 5-hydroxytryptamine receptor 3A Gene

Htr3a - 5-hydroxytryptamine receptor 3A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：5-羟色胺受体 3A

种属: Rattus norvegicus

同用名: 5HT3; Htr3; 5-HT3; 5-HT3A

基因 ID: 79246 | 基因类型: protein coding

关于 Htr3a

Primary_assembly 8: 49,242,020-49,254,389 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 215 orthologues, 41 paralogues and is associated with 6 phenotypes. Biased expression in Brain (RPKM 17.), Testes (RPKM 1.3) and 1 other tissue.

功能概要

该基因编码的蛋白可启动血清素门控阳离子选择性通道活动。参与多个过程，包括离子跨膜转运蛋白活性的正调节；对可卡因的反应；和对乙醇的反应。位于多个细胞成分中，包括轴突；神经细胞体；和质膜。在谷氨酸能突触中活跃。是突触后膜的组成部分和突触前膜的组成部分。该基因的人类直系同源物与肠易激综合征有关。与人 HTR3A（5-羟色胺受体 3A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables serotonin-gated cation-selective channel activity. Involved in several processes, including positive regulation of ion transmembrane transporter activity; response to cocaine; and response to ethanol. Located in several cellular components, including axon; neuronal cell body; and plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in irritable bowel syndrome. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A). [provided by Alliance of Genome Resources, Apr 2022]

Htr3a 基因产物(1)

mRNA Protein Name
NM_024394.3 NP_077370.2 5-hydroxytryptamine receptor 3A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables serotonin-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
12196560 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to ethanol IEP
IEP: 通过表达模式推断
25722691 RGD
involved in cellular response to growth factor stimulus IEP
IEP: 通过表达模式推断
10854267 RGD
involved in positive regulation of ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
10854267 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
17105936 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
16876304 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
17650111 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11876772 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
17650111 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
11876772 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
11876772 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Htr3a 蛋白结构

LIC

LIC: TIGR00860 (4 - 481)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 3A

5-HT-3

5-HT3 receptor

5-HT3-A

5-HT3R

5-hydroxytryptamine (serotonin) receptor 3A, ionotropic

5-hydroxytryptamine receptor 3

serotonin receptor 3A

serotonin-gated ion channel receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06470 HTR3A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06471 Htr3a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06472 Htr3a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Htr3a NCBI NCBI:3359
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