FCRL2 - Fc receptor like 2 Gene

中文名称：Fc 受体样 2

种属: Homo sapiens

同用名: FCRH2; IFGP4; IRTA4; SPAP1; CD307b; SPAP1A; SPAP1B; SPAP1C

关于 FCRL2

功能概要

该基因编码免疫球蛋白受体超家族的一个成员，是聚集在 1 号染色体长臂上的几种 Fc 受体样糖蛋白之一。编码的蛋白质具有四个细胞外 C2 型免疫球蛋白结构域、一个跨膜结构域和一个胞质结构域，其中包含一个免疫受体-酪氨酸激活基序和两个免疫受体-酪氨酸抑制基序。这种蛋白质可能是慢性淋巴细胞白血病的预后标志物。已经描述了选择性剪接的转录本变体，但尚未确定它们的生物学有效性。[RefSeq 提供，2009 年 4 月]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009]