CORO7 - coronin 7 Gene

中文名称：冠宁 7

种属: Homo sapiens

同用名: CRN7; POD1; 0610011B16Rik

关于 CORO7

功能概要

该基因编码 coronin 蛋白家族的一个成员。然而，与其他冠状蛋白不同，它不是肌动蛋白结合蛋白，而是作为 F-肌动蛋白调节剂发挥作用，指导顺行高尔基体进行核内体运输。编码的蛋白质有两个串联的 WD-40 结构域重复序列并定位于跨高尔基体网络。该蛋白质通过 E3 连接酶复合物进行 K33 连接的多泛素化。它被认为在维持高尔基体形态方面发挥重要作用。可变剪接导致多个转录本变体；其中一些与邻近基因形成通读转录本。[RefSeq 提供，2016 年 12 月]

This gene encodes a member of the coronin protein family. However, unlike Other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 Ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]