1. Gene
  2. DHX40 - DEAH-box helicase 40 Gene

DHX40 - DEAH-box helicase 40 Gene

中文名称:DEAH 盒解旋酶 40

种属: Homo sapiens

同用名: PAD; DDX40; ARG147

基因 ID: 79665 | 基因类型: protein coding

关于 DHX40

Cytogenetic location: 17q23.1 Genomic coordinates (GRCh38): 17:59,565,610-59,608,345 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 20.7), thyroid (RPKM 19.9) and 25 other tissues.

功能概要

该基因编码 ATP 依赖性 RNA 解旋酶 DExH/D 盒家族的成员,该解旋酶在 RNA 代谢中具有重要作用。交替剪接导致多个转录本变体。在 17 号染色体上发现了该基因的假基因。[RefSeq 提供,2009 年 10 月]

This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Oct 2009]

DHX40 基因产物(2)

mRNA Protein Name
NM_001166301.2 NP_001159773.1 probable ATP-dependent RNA helicase DHX40 isoform 2
NM_024612.5 NP_078888.4 probable ATP-dependent RNA helicase DHX40 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DHX40 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (55 - 216)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (312 - 400)

HA2

HA2: Helicase associated domain (HA2) (462 - 547)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (592 - 698)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
蛋白主名 其他名称

probable ATP-dependent RNA helicase DHX40

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 40 (RNA helicase)

DHX40 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DHX40 Q8IX18 PSTPIP1 Homo sapiens O43586
Y2H Array
32296183
种属内
DHX40 Q8IX18 PSTPIP1 Homo sapiens O43586
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 17

RP17

Retinitis Pigmentosa-17

Retinitis Pigmentosa, Type 17

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus DHX40 VGNC VGNC:61484
Rattus norvegicus DHX40 RGD RGD:1359618
Canis familiaris DHX40 VGNC VGNC:39949
Macaca mulatta DHX40 VGNC VGNC:104597
Mus musculus DHX40 MGD MGI:1914737
Bos taurus DHX40 VGNC VGNC:28056