MORC4 - MORC family CW-type zinc finger 4 Gene

中文名称：MORC 家族 CW 型锌指 4

种属: Homo sapiens

同用名: ZCW4; ZCWCC2; dJ75H8.2

基因 ID: 79710 | 基因类型: protein coding

关于 MORC4

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:106,940,738-107,000,212 (from NCBI)

This gene has 4 transcripts (splice variants), 314 orthologues and 1 paralogue. Broad expression in placenta (RPKM 38.5), adrenal (RPKM 15.2) and 18 other tissues.

功能概要

在人类中，小卵 (morc) 基因家族的四个当前成员共享一个 N 末端 ATP 酶样 ATP 结合区域和一个 CW 四半胱氨酸锌指基序。由该基因编码的蛋白质还具有核基质结合结构域和靠近其 C 末端的双链卷曲螺旋基序。该基因在正常组织中以低水平广泛表达，在胎盘和睾丸中表达升高。可变剪接导致编码不同蛋白质的多个转录变体。[RefSeq 提供，2010 年 1 月]

In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

MORC4 基因产物(2)

mRNA	Protein	Name
NM_001085354.3	NP_001078823.1	MORC family CW-type zinc finger protein 4 isoform b
NM_024657.5	NP_078933.3	MORC family CW-type zinc finger protein 4 isoform a

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables methylated histone binding	IDA IDA: 通过直接分析推断	26933034	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21988832	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MORC4 蛋白结构

HATPase_c_3

zf-CW

0
200
400
600
800
937 a.a.

蛋白主名

其他名称

MORC family CW-type zinc finger protein 4

zinc finger CW-type coiled-coil domain protein 2

MORC4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MORC4	Q8TE76	STAT3	Homo sapiens	P40763	Pull Down	21988832

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Charcot-Marie-Tooth Disease, Axonal, Type 2z

CMT2Z	Charcot-Marie-Tooth Disease Axonal Type 2z
Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2z	Charcot-Marie-Tooth Neuropathy, Type 2z
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2z	Charcot-Marie-Tooth Neuropathy Type 2z
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2z	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Morc2 Mutation
Charcot-Marie-Tooth Disease 2z	Charcot-Marie-Tooth Disease, Type 2z

Lynch Syndrome I

Lynch Syndrome 1	Colorectal Cancer, Hereditary Nonpolyposis, Type 1
HNPCC1	Fcc1
Lynch Syndrome Ii	Colon Cancer, Familial Nonpolyposis, Type 1
Coca1	Familial Nonpolyposis Colon Cancer Type 1
Hereditary Nonpolyposis Colorectal Cancer Type 1	Hereditary Non-Polyposis Colorectal Cancer 1
Hereditary Non-Polyposis Colorectal Cancer 3	Hnpcc3
Lynch Cancer Family Syndrome	Lynch Syndrome
Lynch Syndrome Type I	Lynch Syndrome Type Ii
Cancer, Colorectal, Nonpolyposis, Hereditary, Type 1	Hereditary Nonpolyposis Colorectal Cancer
Colorectal Cancer, Hereditary Nonpolyposis, Type 3	Hereditary Non-Polyposis Colon Cancer Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08592	MORC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	MORC4	RGD	RGD:1559905
Mus musculus	MORC4	MGD	MGI:1922996
Macaca mulatta	MORC4	VGNC	VGNC:74808
Canis familiaris	MORC4	VGNC	VGNC:43319
Felis catus	MORC4	VGNC	VGNC:63559

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