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  2. IPO4 - importin 4 Gene

IPO4 - importin 4 Gene

中文名称:导入 4

种属: Homo sapiens

同用名: Imp4

基因 ID: 79711 | 基因类型: protein coding

关于 IPO4

This gene has 21 transcripts (splice variants), 1 gene allele, 195 orthologues and 5 paralogues. Broad expression in testis (RPKM 33.8), thyroid (RPKM 8.4) and 25 other tissues.

功能概要

预测启用核输入信号受体活性和核定位序列结合活性。参与 DNA 复制依赖性染色质组装;不依赖于 DNA 复制的染色质组装;和蛋白质输入细胞核。位于染色质中。部分含蛋白质复合物。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in DNA replication-dependent chromatin assembly; DNA replication-independent chromatin assembly; and protein import into nucleus. Located in chromatin. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

IPO4 基因产物(1)

mRNA Protein Name
NM_024658.4 NP_078934.3 importin-4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear import signal receptor activity IDA
IDA: 通过直接分析推断
16207705 GOA
enables nuclear localization sequence binding IDA
IDA: 通过直接分析推断
17682055 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17616579 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
11823430 GOA
involved in protein localization to nucleus IDA
IDA: 通过直接分析推断
14718166 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
14718166 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
14718166 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IPO4 蛋白结构

IBN_N

IBN_N: Importin-beta N-terminal domain (24 - 88)

HEAT_2

HEAT_2: HEAT repeats (399 - 505)

HEAT_EZ

HEAT_EZ: HEAT-like repeat (913 - 968)

  • 0
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  • 1000
  • 1081 a.a.
蛋白主名 其他名称

importin-4

imp4b

IPO4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IPO4 Q8TEX9 TCP11L1 Homo sapiens Q9NUJ3 32296183
种属内
IPO4 Q8TEX9 CEBPD Homo sapiens P49716 20805509
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I

Cda I

CDAN1A

Congenital Dyserythropoietic Anemia Type 1

Congenital Dyserythropoietic Anemia Type Ia

Congenital Dyserythropoietic Anemia, Type I

Anemia, Congenital Dyserythropoietic, Type I

Cda Type 1

Cda Type I

Cda Ia

Dyserythropoietic Anemia, Congenital Type 1

Anemia, Congenital Dyserythropoietic, Type 1a

Dyserythropoietic Anemia, Congenital, Type Ia

Cda, Type Ia

Congenital Dyserythropoietic Anaemia Type 1

Congenital Dyserythropoietic Anaemia Type I

Anemia, Dyserythropoietic, Congenital Type 1

Type I Congenital Dyserythropoietic Anemia

Anemia, Congenital Dyserythropoietic, 1a

Anemia, Dyserythropoietic, Congenital, Type Ia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta IPO4 VGNC VGNC:73630
Mus musculus IPO4 MGD MGI:1923001
Felis catus IPO4 VGNC VGNC:62955
Canis familiaris IPO4 VGNC VGNC:42065
Rattus norvegicus IPO4 RGD RGD:1305206
Bos taurus IPO4 VGNC VGNC:30242