LIN28A - lin-28 homolog A Gene

中文名称：lin-28 同系物 A

种属: Homo sapiens

同用名: CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A

基因 ID: 79727 | 基因类型: protein coding

关于 LIN28A

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,410,817-26,429,728 (from NCBI)

This gene has 2 transcripts (splice variants), 303 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 1.6).

功能概要

该基因编码一种 LIN-28 家族 RNA 结合蛋白，作为参与胚胎干细胞发育时间和自我更新的基因的转录后调节因子。编码的蛋白质通过与目标 mRNA 的直接相互作用和破坏参与胚胎发育的某些 miRNA 的成熟来发挥作用。这种蛋白质阻止了 LET7 MicroRNA 家族的末端加工，而 LET7 家族是细胞生长和分化的主要调节因子。该基因的异常表达与多种组织中的癌症进展有关。[RefSeq 提供，2015 年 9 月]

This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of MicroRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with Cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]

LIN28A 基因产物(1)

mRNA	Protein	Name
NM_024674.6	NP_078950.1	protein lin-28 homolog A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IDA IDA: 通过直接分析推断	19703396	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	21247876	GOA
enables pre-miRNA binding	IDA IDA: 通过直接分析推断	21247876	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19703396	GOA
enables protein-RNA adaptor activity	IDA IDA: 通过直接分析推断	18951094	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in RNA 3'-end processing	IMP IMP: 通过突变表型推断	19703396	GOA
involved in miRNA catabolic process	IMP IMP: 通过突变表型推断	19703396	GOA
involved in negative regulation of pre-miRNA processing	IDA IDA: 通过直接分析推断	21247876	GOA
involved in positive regulation of cytoplasmic translation	IMP IMP: 通过突变表型推断	21247876	GOA
involved in pre-miRNA processing	IMP IMP: 通过突变表型推断	19703396	GOA
involved in stem cell population maintenance	IMP IMP: 通过突变表型推断	19703396	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in P-body	IDA IDA: 通过直接分析推断	17617744	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18604195	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	17617744	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17617744	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LIN28A 蛋白结构

CSD

zf-CCHC

0
100
209 a.a.

蛋白主名

其他名称

protein lin-28 homolog A

RNA-binding protein LIN-28

关联疾病

疾病名称

别名

Medulloepithelioma

Diktyoma, Malignant	Medulloepithelioma, Central Nervous System
Medulloepithelioma Of The Central Nervous System

Central Nervous System Primitive Neuroectodermal Neoplasm

Cpnet

Embryonal Tumor With Multilayered Rosettes, C19mc-Altered

Ependymoblastoma

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor	PRLMNS
Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism	Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor
Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor	Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor
Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism	Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome
Renal Hamartomas Nephroblastomatosis And Fetal Gigantism	Nephroblastoma
Fetal Macrosomia

Acrocephalopolysyndactyly Type Iii

Sakati Syndrome	Sakati-Nyhan Syndrome
Acps With Leg Hypoplasia	Acps Iii
Acrocephalopolysyndactyly Type 3	Sakati-Nyhan-Tisdale Syndrome

Inflammatory Bowel Disease 7

IBD7

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome	Rtps
Atypical Teratoid/Rhabdoid Tumor	Rhabdoid Predisposition Syndrome
Familial Posterior Fossa Brain Tumor Of Infancy	Familial Rhabdoid Tumor
At/Rt	Atypical Teratoid Rhabdoid Tumour
Atypical Teratoid/Rhabdoid Tumour	Rhabdoid Tumor Of The Cns
Rhabdoid Tumour Of The Cns	Familial Posterior Fossa Brain Tumor Syndrome
Hereditary Swi/Snf Deficiency Syndrome	Atrt

Mature Teratoma

Dermoid Cyst

Benign Teratoma

Supratentorial Cancer

Supratentorial Neoplasms	Brain Neoplasm, Supratentorial
Malignant Supratentorial Tumor	Cancer, Supratentorial

Malignant Teratoma

Immature Teratoma	Malignant Extragonadal Teratoma
Primary Malignant Extragonadal Teratoma	Teratoma, Malignant, Nos
Teratoma, Malignant	Immature Extragonadal Teratoma

Cerebrum Cancer

Cerebral Cancer	Neoplasm Of Cerebrum
Tumor Of Cerebrum	Malignant Neoplasm Of Cerebrum

Retinitis Pigmentosa 50

RP50	Retinitis Pigmentosa, Concentric
Retinitis Pigmentosa-50	Retinitis Pigmentosa Concentric

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100692	Lin28-let-7a antagonist 1	Antagonist	99.48%	否
HY-112659	Lin28-let-7 antagonist 1	Antagonist	99.68%	否
HY-RS07671	LIN28A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	LIN28A	VGNC	VGNC:42683
Felis catus	LIN28A	VGNC	VGNC:63231
Mus musculus	LIN28A	MGD	MGI:1890546
Rattus norvegicus	LIN28A	RGD	RGD:1566408

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LIN28A - lin-28 homolog A Gene

关于 LIN28A

功能概要

LIN28A 基因产物(1)

LIN28A 蛋白结构

关联疾病

直系同源

热门区域

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LIN28A - lin-28 homolog A Gene

关于 LIN28A

功能概要

LIN28A 基因产物(1)

LIN28A 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z