2. Gene
  3. RPP21 - ribonuclease P/MRP subunit p21 Gene

RPP21 - ribonuclease P/MRP subunit p21 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖核酸酶 P/MRP 亚基 p21

种属: Homo sapiens

同用名: CAT60; C6orf135

基因 ID: 79897 | 基因类型: protein coding

关于 RPP21

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,345,156-30,346,857 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 162 orthologues. Ubiquitous expression in endometrium (RPKM 10.7), ovary (RPKM 10.6) and 25 other tissues.

功能概要

RPP21 是核糖核酸酶 P 的一个蛋白质亚基，它处理前体 tRNA 的 5-prime 前导序列 (Jarrous 等人，2001 [PubMed 11497433]) 。[OMIM 提供，2009 年 1 月]

RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

RPP21 基因产物(3)

mRNA Protein Name
NM_001199120.3 NP_001186049.1 ribonuclease P protein subunit p21 isoform 1
NM_001199121.3 NP_001186050.1 ribonuclease P protein subunit p21 isoform 3
NM_024839.4 NP_079115.1 ribonuclease P protein subunit p21 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15096576 GOA
enables ribonuclease P RNA binding IDA
IDA: 通过直接分析推断
16723659 GOA
contributes to ribonuclease P activity IDA
IDA: 通过直接分析推断
30454648 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18291362 GOA
involved in tRNA 5'-leader removal IDA
IDA: 通过直接分析推断
16723659 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of multimeric ribonuclease P complex IDA
IDA: 通过直接分析推断
16723659 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPP21 蛋白结构

Rpr2

Rpr2: RNAse P Rpr2/Rpp21/SNM1 subunit domain (12 - 97)

  • 0
  • 100
  • 154 a.a.
蛋白主名 其他名称

ribonuclease P protein subunit p21

RNaseP protein p21

关联疾病

疾病名称 别名
Anauxetic Dysplasia 2

ANXD2
Anauxetic Dysplasia 1

Anauxetic Dysplasia

Spondylometaepiphyseal Dysplasia, Menger Type

Spondylometaepiphyseal Dysplasia, Anauxetic Type

Spondyloepimetaphyseal Dysplasia, Anauxetic Type

ANXD1

Anxd

Spondylometaepiphyseal Dysplasia Anauxetic Type

Spondylometaepiphyseal Dysplasia Menger Type

Ad

Spondyloepimetaphyseal Dysplasia, Menger Type

Dysplasia, Anauxetic, Type 1
Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type

CHH

Mckusick Type Metaphyseal Chondrodysplasia

Metaphyseal Dysplasia Without Hypotrichosis

Cartilage Hair Hypoplasia Like Syndrome

Metaphyseal Chondrodysplasia Mckusick Type

Chhv

Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

Cartilage-Hair Syndrome

Mckusick'S Metaphyseal Chondrodysplasia Syndrome

Metaphyseal Chondrodysplasia, Recessive Type

Autosomal Recessive Metaphyseal Chondrodysplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12213 RPP21 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RPP21 VGNC VGNC:102509
Bos taurus RPP21 VGNC VGNC:106902
Canis familiaris RPP21 VGNC VGNC:54354
Rattus norvegicus RPP21 RGD RGD:1303090
Mus musculus RPP21 MGD MGI:1914926
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