2. Gene
  3. SETD6 - SET domain containing 6, protein lysine methyltransferase Gene

SETD6 - SET domain containing 6, protein lysine methyltransferase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 SET 结构域 6，蛋白赖氨酸甲基转移酶

种属: Homo sapiens

基因 ID: 79918 | 基因类型: protein coding

关于 SETD6

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,515,479-58,523,842 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 13.6), skin (RPKM 9.3) and 25 other tissues.

功能概要

该基因编码一种甲基转移酶，可将甲基添加到组蛋白 H2AZ 中，该组蛋白参与核受体依赖性转录。该蛋白质还与参与核激素受体信号传导的几种内源性蛋白质相互作用。一个相关的假基因位于 2 号染色体上。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

SETD6 基因产物(2)

mRNA Protein Name
NM_001160305.4 NP_001153777.1 N-lysine methyltransferase SETD6 isoform a
NM_024860.3 NP_079136.2 N-lysine methyltransferase SETD6 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NF-kappaB binding IPI
IPI: 通过物理相互作用推断
21131967 GOA
enables S-adenosyl-L-methionine binding IDA
IDA: 通过直接分析推断
21515635 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21131967 GOA
enables protein-lysine N-methyltransferase activity IDA
IDA: 通过直接分析推断
21131967 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
21131967 GOA
involved in peptidyl-lysine monomethylation IDA
IDA: 通过直接分析推断
21131967 GOA
involved in regulation of inflammatory response IMP
IMP: 通过突变表型推断
21131967 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
21131967 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SETD6 蛋白结构

SET

SET: SET domain (74 - 286)

Rubis-subs-bind

Rubis-subs-bind: Rubisco LSMT substrate-binding (334 - 465)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
蛋白主名 其他名称

N-lysine methyltransferase SETD6

SET domain-containing protein 6

SETD6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
SETD6 Q8TBK2 Rela Mus musculus Q04207
Methyltransferase Ass
21131967
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 30

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency

IMD30

Il12rb1 Deficiency

Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency

Msmd Due To Complete Il12rb1 Deficiency

Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency

Il-12râ1 Deficiency

Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency

Immunodeficiency, Type 30
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12746 SETD6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SETD6 MGD MGI:1913333
Macaca mulatta SETD6 VGNC VGNC:77313
Felis catus SETD6 VGNC VGNC:65045
Canis familiaris SETD6 VGNC VGNC:46057
Rattus norvegicus SETD6 RGD RGD:1560538
Bos taurus SETD6 VGNC VGNC:34496
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