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  2. JADE1 - jade family PHD finger 1 Gene

JADE1 - jade family PHD finger 1 Gene

中文名称:翡翠家族 PHD 手指 1

种属: Homo sapiens

同用名: PHF17

基因 ID: 79960 | 基因类型: protein coding

关于 JADE1

Cytogenetic location: 4q28.2 Genomic coordinates (GRCh38): 4:128,809,700-128,875,224 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 13.1), ovary (RPKM 12.4) and 25 other tissues.

功能概要

启用转录共激活因子活性。参与组蛋白乙酰化和经典 Wnt 信号通路的负调控。在有丝分裂细胞周期的 G1/S 转换负调节的上游或负调节中起作用。位于几种细胞成分中,包括睫状基体;胞质溶胶;和核斑点。组蛋白乙酰转移酶复合物的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables transcription coactivator activity. Involved in histone acetylation and negative regulation of canonical Wnt signaling pathway. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including ciliary basal body; cytosol; and nuclear speck. Part of Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

JADE1 基因产物(8)

mRNA Protein Name
NM_001287437.2 NP_001274366.1 protein Jade-1 isoform 3
NM_001287439.2 NP_001274368.1 protein Jade-1 isoform 1
NM_001287440.2 NP_001274369.1 protein Jade-1 isoform 1
NM_001287441.2 NP_001274370.1 protein Jade-1 isoform 2
NM_001287442.1 NP_001274371.1 protein Jade-1 isoform 1
NM_001287443.1 NP_001274372.1 protein Jade-1 isoform 1
NM_024900.5 NP_079176.2 protein Jade-1 isoform 2
NM_199320.4 NP_955352.1 protein Jade-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to histone H3K14 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
contributes to histone H4K12 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
NOT contributes to histone H4K16 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
contributes to histone H4K5 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
contributes to histone H4K8 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12169691 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
23001567 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
23001567 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
22654112 GOA
involved in regulation of DNA biosynthetic process IDA
IDA: 通过直接分析推断
16387653 GOA
involved in regulation of DNA replication IDA
IDA: 通过直接分析推断
16387653 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
22144582 GOA
involved in regulation of cell cycle IDA
IDA: 通过直接分析推断
16387653 GOA
involved in regulation of cell growth IDA
IDA: 通过直接分析推断
22144582 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in ciliary basal body IDA
IDA: 通过直接分析推断
22654112 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12169691 GOA
located in cytosol IDA
IDA: 通过直接分析推断
24739512 GOA
part of histone acetyltransferase complex IDA
IDA: 通过直接分析推断
16387653 GOA
part of histone acetyltransferase complex IPI
IPI: 通过物理相互作用推断
16387653 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
12169691 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
16387653 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12169691 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
23001567 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

JADE1 蛋白结构

EPL1

EPL1: Enhancer of polycomb-like (39 - 180)

PHD_2

PHD_2: PHD-finger (218 - 251)

zf-HC5HC2H_2

zf-HC5HC2H_2: PHD-zinc-finger like domain (257 - 368)

  • 0
  • 200
  • 400
  • 600
  • 842 a.a.
蛋白主名 其他名称

protein Jade-1

PHD finger protein 17

JADE1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
JADE1 Q6IE81 YJU2 Homo sapiens Q9BW85
Validated Y2H
25416956
种属内
JADE1 Q6IE81 YJU2 Homo sapiens Q9BW85
Y2H Array
25416956
种属内
JADE1 Q6IE81 NPHP4 Homo sapiens O75161
IF
22654112
种属内
JADE1 Q6IE81 NPHP4 Homo sapiens O75161
Anti Tag CoIP
22654112
种属内
JADE1 Q6IE81 KAT7 Homo sapiens O95251
TAP
24981860
种属内
JADE1 Q6IE81 KAT7 Homo sapiens O95251
Anti Tag CoIP
33961781
种属内
JADE1 Q6IE81 KAT7 Homo sapiens O95251
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Atrophy Of Testis

Atrophic Testicle

Atrophy Of Testicle

Testicular Atrophy

Neuropathy, Hereditary Sensory And Autonomic, Type Iia

Hereditary Sensory And Autonomic Neuropathy Type 2

Hsan2

HSAN2A

Morvan Disease

Hereditary Sensory And Autonomic Neuropathy Type Ii

Neurogenic Acroosteolysis

Hsan Iia

Hsn2a

Hsn Iia

Neuropathy, Progressive Sensory, Of Children

Neuropathy, Congenital Sensory

Neuropathy, Hereditary Sensory And Autonomic, Type Ii

Hereditary Sensory And Autonomic Neuropathy Type 2a

Hereditary Sensory And Autonomic Neuropathy Type Iia

Hsanii

Congenital Sensory Neuropathy

Hsan Type Ii

Morvan Syndrome

Neuropathy, Hereditary Sensory And Autonomic, Type 2a

Morvan'S Disease

Neuropathy, Hereditary Sensory, Type Iia

Acroosteolysis, Neurogenic

Acroosteolysis, Giaccai Type

Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive

Hereditary Sensory Autonomic Neuropathy Type 2

Giaccai Type Acroosteolysis

Hereditary Sensory Neuropathy Type 2

Hereditary Sensory Radicular Neuropathy, Recessive Form

Hsan2b

Hsan2c

Hsan2d

Hsn Type Ii

Autosomal Recessive Sensory Radicular Neuropathy

Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome

Morvan Fibrillary Chorea

Neuropathy, Hereditary Sensory And Autonomic, 2a

Acroosteolysis Giaccai Type

Hereditary Sensory Neuropathy Type Iia

Hereditary Sensory Radicular Neuropathy Autosomal Recessive

Progressive Sensory Neuropathy Of Children

Neuropathy Congenital Sensory

Charcot-Marie-Tooth Disease

Neuropathy, Sensory And Autonomic, Hereditary, Type Iia

Hereditary Sensory Autonomic Neuropathy, Type 2

Hereditary Motor And Sensory-Neuropathy Type Ii

Sensory Neuropathy, Hereditary

Neuropathy, Hereditary Sensory And Autonomic, Type Iib

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus JADE1 VGNC VGNC:30358
Macaca mulatta JADE1 VGNC VGNC:73687
Rattus norvegicus JADE1 RGD RGD:1306920
Felis catus JADE1 VGNC VGNC:62995
Mus musculus JADE1 MGD MGI:1925835
Canis familiaris JADE1 VGNC VGNC:42169