2. Gene
  3. KAT7 - lysine acetyltransferase 7 Gene

KAT7 - lysine acetyltransferase 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：赖氨酸乙酰转移酶 7

种属: Homo sapiens

同用名: HBO1; HBOA; MYST2; ZC2HC7

基因 ID: 11143 | 基因类型: protein coding

关于 KAT7

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,788,681-49,835,026 (from NCBI)

This gene has 19 transcripts (splice variants), 267 orthologues, 9 paralogues and is associated with 64 phenotypes. Broad expression in testis (RPKM 37.1), bone marrow (RPKM 22.8) and 24 other tissues.

功能概要

该基因编码的蛋白质是多聚体 HBO1 复合物的一部分，它具有组蛋白 H4 特异性乙酰转移酶活性。此活动是功能性复制起点所必需的，并且参与某些基因的转录激活。在这两种情况下，组蛋白 H4 的乙酰化有助于展开染色质，从而可以访问、复制或转录 DNA。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]

KAT7 基因产物(6)

mRNA Protein Name
NM_001199155.2 NP_001186084.1 histone acetyltransferase KAT7 isoform 2
NM_001199156.2 NP_001186085.1 histone acetyltransferase KAT7 isoform 3
NM_001199157.2 NP_001186086.1 histone acetyltransferase KAT7 isoform 4
NM_001199158.2 NP_001186087.1 histone acetyltransferase KAT7 isoform 5
NM_001346706.2 NP_001333635.1 histone acetyltransferase KAT7 isoform 6
NM_007067.5 NP_008998.1 histone acetyltransferase KAT7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA replication origin binding IMP
IMP: 通过突变表型推断
21856198 GOA
enables histone H3K14 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
enables histone H3K23 acetyltransferase activity IDA
IDA: 通过直接分析推断
24065767 GOA
enables histone H3K4 acetyltransferase activity IMP
IMP: 通过突变表型推断
21856198 GOA
enables histone H4 acetyltransferase activity IDA
IDA: 通过直接分析推断
24065767 GOA
enables histone H4K12 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
NOT enables histone H4K16 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
enables histone H4K5 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
enables histone H4K8 acetyltransferase activity IDA
IDA: 通过直接分析推断
16387653 GOA
enables histone acetyltransferase activity IDA
IDA: 通过直接分析推断
28719581 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10930412 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA replication-dependent chromatin disassembly IDA
IDA: 通过直接分析推断
16387653 GOA
involved in internal peptidyl-lysine acetylation IDA
IDA: 通过直接分析推断
26221039 GOA
involved in positive regulation of DNA replication IDA
IDA: 通过直接分析推断
26620551 GOA
involved in positive regulation of hematopoietic stem cell proliferation IDA
IDA: 通过直接分析推断
31827282 GOA
involved in positive regulation of protein localization to nucleus IDA
IDA: 通过直接分析推断
24739512 GOA
involved in regulation of DNA biosynthetic process IDA
IDA: 通过直接分析推断
16387653 GOA
involved in regulation of DNA replication IDA
IDA: 通过直接分析推断
16387653 GOA
involved in regulation of DNA-templated DNA replication initiation IDA
IDA: 通过直接分析推断
26620551 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
22144582 GOA
involved in regulation of cell cycle IDA
IDA: 通过直接分析推断
16387653 GOA
involved in regulation of cell growth IDA
IDA: 通过直接分析推断
22144582 GOA
involved in regulation of nucleotide-excision repair IDA
IDA: 通过直接分析推断
28719581 GOA
involved in response to actinomycin D IMP
IMP: 通过突变表型推断
21856198 GOA
involved in response to anisomycin IMP
IMP: 通过突变表型推断
21856198 GOA
involved in response to dithiothreitol IMP
IMP: 通过突变表型推断
21856198 GOA
involved in response to hydroxyurea IMP
IMP: 通过突变表型推断
21856198 GOA
involved in response to sorbitol IMP
IMP: 通过突变表型推断
21856198 GOA
involved in stress-activated protein kinase signaling cascade IDA
IDA: 通过直接分析推断
21856198 GOA
involved in transcription initiation-coupled chromatin remodeling IMP
IMP: 通过突变表型推断
21856198 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome IDA
IDA: 通过直接分析推断
24065767 GOA
part of histone H3-K14 acetyltransferase complex IDA
IDA: 通过直接分析推断
21753189 GOA
part of histone acetyltransferase complex IDA
IDA: 通过直接分析推断
16387653 GOA
part of histone acetyltransferase complex IPI
IPI: 通过物理相互作用推断
16387653 GOA
NOT located in nucleolus IDA
IDA: 通过直接分析推断
16387653 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
16387653 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21753189 GOA
located in site of DNA damage IDA
IDA: 通过直接分析推断
28719581 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KAT7 蛋白结构

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (183 - 212)

MOZ_SAS

MOZ_SAS: MOZ/SAS family (390 - 574)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 611 a.a.
蛋白主名 其他名称

histone acetyltransferase KAT7

K(lysine) acetyltransferase 7

KAT7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
KAT7 O95251 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
种属内
KAT7 O95251 VIM Homo sapiens P08670
Y2H
21900206
种属内
KAT7 O95251 CEP126 Homo sapiens Q9P2H0
Y2H
15383276
种属内
KAT7 O95251 AR Homo sapiens P10275
Anti Tag CoIP
10930412
种属内
KAT7 O95251 AR Homo sapiens P10275
Y2H
10930412
种属内
KAT7 O95251 JADE1 Homo sapiens Q6IE81
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

KAT7 抗体

目录号 产品名 应用 反应物种
HY-P83282 KAT7 Antibody (YA3027) WB, IHC-F, IHC-P, ICC/IF, IP Human

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134901 WM-3835 99.78% 否
HY-102058 WM-1119 Inhibitor 99.57% 否
HY-RS07083 KAT7 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus KAT7 MGD MGI:2182799
Felis catus KAT7 VGNC VGNC:63026
Macaca mulatta KAT7 VGNC VGNC:99160
Bos taurus KAT7 VGNC VGNC:30403
Canis familiaris KAT7 VGNC VGNC:42214
Rattus norvegicus KAT7 RGD RGD:727966
Others KAT7 NCBI
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