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  2. STN1 - STN1 subunit of CST complex Gene

STN1 - STN1 subunit of CST complex Gene

中文名称:CST 复合体的 STN1 亚基

种属: Homo sapiens

同用名: AAF44; OBFC1; AAF-44; RPA-32; bA541N10.2

基因 ID: 79991 | 基因类型: protein coding

关于 STN1

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,877,569-103,918,184 (from NCBI)

This gene has 20 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in testis (RPKM 3.8), lung (RPKM 3.8) and 25 other tissues.

功能概要

OBFC1 和 C17ORF68 (MIM 613129) 是 alpha 辅助因子 (AAF) 的亚基,可刺激 DNA 聚合酶-α-引发酶的活性 (参见 MIM 176636) ,该酶可启动 DNA 复制 (Casteel 等人,2009 [PubMed 19119139) ]) . OBFC1 似乎也与 C17ORF68 和 TEN1 (C17ORF106;MIM 613130) 一起在端粒相关复合体中发挥作用 (Miyake 等人,2009 [PubMed 19854130]) 。[OMIM 提供,2009 年 11 月]

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the Enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

STN1 基因产物(1)

mRNA Protein Name
NM_024928.5 NP_079204.2 CST complex subunit STN1

STN1 蛋白结构

tRNA_anti-codon

tRNA_anti-codon: OB-fold nucleic acid binding domain (59 - 152)

STN1_2

STN1_2: CST, Suppressor of cdc thirteen homolog, complex subunit STN1 (157 - 334)

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  • 368 a.a.
蛋白主名 其他名称

CST complex subunit STN1

STN1, CST complex subunit

STN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STN1 Q9H668 RCOR3 Homo sapiens Q9P2K3-2 32296183
种属内
STN1 Q9H668 TPP1 Homo sapiens O14773-1
Y2H
22763445
种属内
STN1 Q9H668 TEN1 Homo sapiens Q86WV5 33961781
种属内
STN1 Q9H668 TEN1 Homo sapiens Q86WV5
Y2H
19854130
种属内
STN1 Q9H668 TEN1 Homo sapiens Q86WV5 28514442
种属内
STN1 Q9H668 CTC1 Homo sapiens Q2NKJ3 33961781
种属内
STN1 Q9H668 CTC1 Homo sapiens Q2NKJ3 28514442
种属内
STN1 Q9H668 CTC1 Homo sapiens Q2NKJ3
Y2H
19854130
种属内
STN1 Q9H668 CTC1 Homo sapiens Q2NKJ3 19854130
种属内
STN1 Q9H668 ACD Homo sapiens Q96AP0 19648609
种属内
STN1 Q9H668 ACD Homo sapiens Q96AP0 19648609
种属内
STN1 Q9H668 C14orf119 Homo sapiens Q9NWQ9 32296183
种属内
STN1 Q9H668 LDLRAP1 Homo sapiens Q5SW96 33961781
种属内
STN1 Q9H668 LDLRAP1 Homo sapiens Q5SW96 25416956
种属内
STN1 Q9H668 LDLRAP1 Homo sapiens Q5SW96 28514442
种属内
STN1 Q9H668 AIRIM Homo sapiens Q9NX04 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 STN1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70981 OBFC1 Protein, Human (His) AAH17400.1 (M1-F368) ≥95%

关联疾病

疾病名称 别名
Cerebroretinal Microangiopathy With Calcifications And Cysts 2

CRMCC2

Cerebroretinal Microangiopathy With Calcifications And Cysts 1

Coats Plus Syndrome

Cerebroretinal Microangiopathy With Calcifications And Cysts

Crmcc

CRMCC1

Microangiopathy, Cerebroretinal, With Calcifications And Cysts

Cerebral Small Vessel Diseases

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis

Ipf

Fibrocystic Pulmonary Dysplasia

Pulmonary Fibrosis, Idiopathic

Pulmonary Fibrosis, Idiopathic, Susceptibility To

Cryptogenic Fibrosing Alveolitis

ILD2

Idiopathic Pulmonary Fibrosis, Familial

Fibrosing Alveolitis, Cryptogenic

Uip

Fibrosing Alveolitis

Interstitial Pneumonitis, Usual

Familial Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis, Chronic Form

Usual Interstitial Pneumonia

Fibrosing Alveolitis Cryptogenic

Hamman-Rich Disease

Idiopathic Pulmonary Fibrosis Familial

Interstitial Pneumonitis Usual

Fibrosis Idiopathic Pulmonary

Fibrosis, Pulmonary, Idiopathic

Hamman-Rich Syndrome

Chronic Idiopathic Pulmonary Fibrosis

Acute Interstitial Pneumonia

Interstitial Pulmonary Fibrosis

Ipf - [Idiopathic Pulmonary Fibrosis]

Idiopathic Lung Fibrosis

Fibrosing Lung Disease

Pulmonary Fibrosis Nos

Fibrosing Pneumonitis

Premature Aging

Syndrome With Premature-Aging

Portal Hypertension

Hypertension, Portal

Hypertension Portal

Pht - [Portal Hypertension]

Portal Htn

Pancytopenia
Spasticity
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome

Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta STN1 VGNC VGNC:78219
Canis familiaris STN1 VGNC VGNC:46930
Felis catus STN1 VGNC VGNC:65791
Bos taurus STN1 VGNC VGNC:35408
Rattus norvegicus STN1 RGD RGD:1305637
Mus musculus STN1 MGD MGI:1915581
Others STN1 NCBI