TEN1 - TEN1 subunit of CST complex Gene

中文名称：CST 复合物的 TEN1 亚基

种属: Homo sapiens

同用名: C17orf106

基因 ID: 100134934 | 基因类型: protein coding

关于 TEN1

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,979,240-76,000,586 (from NCBI)

This gene has 5 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in small intestine (RPKM 13.6), fat (RPKM 12.7) and 25 other tissues.

功能概要

C17ORF106 或 TEN1 似乎在与 STN1 (OBFC1；MIM 613128) 和 CTC1 (C17ORF68；MIM 613129) 的端粒相关复合体中起作用 (Miyake 等人，2009 [PubMed 19854130]) 。[OMIM 提供，2009 年 11 月] ]

C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

TEN1 基因产物(1)

mRNA	Protein	Name
NM_001113324.3	NP_001106795.2	CST complex subunit TEN1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	19854130	GOA
enables telomeric DNA binding	IDA IDA: 通过直接分析推断	19854130	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of telomere maintenance via telomerase	IDA IDA: 通过直接分析推断	22763445	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CST complex	IDA IDA: 通过直接分析推断	19854130	GOA
located in chromosome, telomeric region	IDA IDA: 通过直接分析推断	19854130	GOA
located in nucleus	IDA IDA: 通过直接分析推断	19854130	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TEN1 蛋白结构

Ten1_2

0
100
123 a.a.

蛋白主名

其他名称

CST complex subunit TEN1

TEN1 telomerase capping complex subunit homolog

TEN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TEN1	Q86WV5	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
种属内	TEN1	Q86WV5	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
种属内	TEN1	Q86WV5	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
种属内	TEN1	Q86WV5	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
种属内	TEN1	Q86WV5	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	LAMP2	Homo sapiens	P13473-2	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	LAMP2	Homo sapiens	P13473-2	Validated Y2H	32814053
种属内	TEN1	Q86WV5	LAMP2	Homo sapiens	P13473-2	Y2H Array	32814053
种属内	TEN1	Q86WV5	CTC1	Homo sapiens	Q2NKJ3	Anti Tag CoIP	33961781
种属内	TEN1	Q86WV5	CTC1	Homo sapiens	Q2NKJ3	Anti Tag CoIP	28514442
种属内	TEN1	Q86WV5	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
种属内	TEN1	Q86WV5	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
种属内	TEN1	Q86WV5	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
种属内	TEN1	Q86WV5	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
种属内	TEN1	Q86WV5	RAN	Homo sapiens	P62826	Y2H Array	32814053
种属内	TEN1	Q86WV5	RAN	Homo sapiens	P62826	Validated Y2H	32814053
种属内	TEN1	Q86WV5	RAN	Homo sapiens	P62826	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
种属内	TEN1	Q86WV5	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
种属内	TEN1	Q86WV5	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
种属内	TEN1	Q86WV5	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
种属内	TEN1	Q86WV5	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
种属内	TEN1	Q86WV5	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
种属内	TEN1	Q86WV5	PRPF40A	Homo sapiens	O75400-2	Validated Y2H	32814053
种属内	TEN1	Q86WV5	PRPF40A	Homo sapiens	O75400-2	Y2H Array	32814053
种属内	TEN1	Q86WV5	PRPF40A	Homo sapiens	O75400-2	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	CASP6	Homo sapiens	P55212	Validated Y2H	32814053
种属内	TEN1	Q86WV5	CASP6	Homo sapiens	P55212	Y2H Array	32814053
种属内	TEN1	Q86WV5	CASP6	Homo sapiens	P55212	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
种属内	TEN1	Q86WV5	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
种属内	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Y2H Prey Pooling	32296183
种属内	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Pull Down	22763445
种属内	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Validated Y2H	32296183
种属内	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Anti Tag CoIP	19854130
种属内	TEN1	Q86WV5	STN1	Homo sapiens	Q9H668	Y2H Array	32296183
种属内	TEN1	Q86WV5	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
种属内	TEN1	Q86WV5	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
种属内	TEN1	Q86WV5	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
种属内	TEN1	Q86WV5	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
种属内	TEN1	Q86WV5	PRPH	Homo sapiens	P41219	Y2H Array	32814053
种属内	TEN1	Q86WV5	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Dyskeratosis Congenita, Autosomal Recessive 6

DKCB6	Autosomal Recessive Dyskeratosis Congenita 6
Dyskeratosis Congenita, Autosomal Recessive, 6	Dyskeratosis Congenita, Autosomal Recessive, Type 6

Dyskeratosis Congenita, Autosomal Recessive 1

DKCB1	Autosomal Recessive Dyskeratosis Congenita 1
Dyskeratosis Congenita, Autosomal Recessive, 1	Dyskeratosis Congenita, Autosomal Recessive, Type 1

Dyskeratosis Congenita, Autosomal Recessive 3

DKCB3	Autosomal Recessive Dyskeratosis Congenita 3
Dyskeratosis Congenita, Autosomal Recessive, 3	Dyskeratosis Congenita, Autosomal Recessive, Type 3

Immunodeficiency 26

Severe Combined Immunodeficiency Due To Dna-Pkcs Deficiency	Scid Due To Dna-Pkcs Deficiency
Imd26	Immunodeficiency 26, With Or Without Neurologic Abnormalities

Retinal Telangiectasia

Revesz Syndrome

Exudative Retinopathy With Bone Marrow Failure	DKCA5
Dyskeratosis Congenita, Autosomal Dominant 5	Dyskeratosis Congenita With Bilateral Exudative Retinopathy
Retinopathy-Anemia-Central Nervous System Anomalies Syndrome	Revesz-Debuse Syndrome
Dyskeratosis Congenita, Autosomal Dominant, 5	Revesz Debuse Syndrome

Glioblastoma Mesenchymal Subtype

Coats Disease

Exudative Retinopathy	Retinal Telangiectasis
Coats' Disease	Leber Miliary Aneurysm
Coats' Syndrome	Congenital Retinal Telangiectasia

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14361	TEN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TEN1	RGD	RGD:1311078
Bos taurus	TEN1	VGNC	VGNC:54498
Canis familiaris	TEN1	VGNC	VGNC:54372
Mus musculus	TEN1	MGD	MGI:1916785

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