1. Gene
  2. PTGES2 - prostaglandin E synthase 2 Gene

PTGES2 - prostaglandin E synthase 2 Gene

中文名称:前列腺素 E 合酶 2

种属: Homo sapiens

同用名: GBF1; GBF-1; PGES2; C9orf15; mPGES-2

基因 ID: 80142 | 基因类型: protein coding

关于 PTGES2

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,120,693-128,128,440 (from NCBI)

This gene has 21 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in heart (RPKM 13.3), kidney (RPKM 10.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种膜相关的前列腺素 E 合酶,它催化前列腺素 H2 转化为前列腺素 E2。这种蛋白质还被证明可以激活由伽马干扰素激活的转录元件 (GATE) 调节的转录。已发现该基因的多个转录变体。[RefSeq 提供,2009 年 6 月]

The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]

PTGES2 基因产物(3)

mRNA Protein Name
NM_001256335.2 NP_001243264.1 prostaglandin E synthase 2 isoform 2
NM_025072.7 NP_079348.1 prostaglandin E synthase 2 isoform 1
NM_198938.3 NP_945176.1 prostaglandin E synthase 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lyase activity IDA
IDA: 通过直接分析推断
17585783 GOA
enables prostaglandin-E synthase activity IDA
IDA: 通过直接分析推断
12804604 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lipid metabolic process IDA
IDA: 通过直接分析推断
17585783 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi membrane IDA
IDA: 通过直接分析推断
12835322 GOA
located in cytosol IDA
IDA: 通过直接分析推断
12835322 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PTGES2 蛋白结构

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (104 - 172)

GST_C_3

GST_C_3: Glutathione S-transferase, C-terminal domain (242 - 368)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
蛋白主名 其他名称

prostaglandin E synthase 2

GATE-binding factor 1

PTGES2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTGES2 Q9H7Z7 CFAP141 Homo sapiens Q5VU69 25416956
种属内
PTGES2 Q9H7Z7 CFAP141 Homo sapiens Q5VU69 25416956
种属间
PTGES2 Q9H7Z7 P0DTD1-PRO_0000449625 SARS-CoV-2 P0DTD1-PRO_0000449625 36217030
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PTGES2 VGNC VGNC:45146
Felis catus PTGES2 VGNC VGNC:64428
Macaca mulatta PTGES2 VGNC VGNC:76505
Bos taurus PTGES2 VGNC VGNC:33506
Rattus norvegicus PTGES2 RGD RGD:1310836
Mus musculus PTGES2 MGD MGI:1917592